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AMERICAN THORACIC SOCIETY
DOCUMENTS
Management of Malignant Pleural Effusions
An Official ATS/STS/STR Clinical Practice Guideline
David J. Feller-Kopman*, Chakravarthy B. Reddy*, Malcolm M. DeCamp, Rebecca L. Diekemper, Michael K. Gould,
Travis Henry, Narayan P. Iyer, Y. C. Gary Lee, Sandra Z. Lewis, Nick A. Maskell, Najib M. Rahman, Daniel H. Sterman,
Momen M. Wahidi, and Alex A. Balekian; on behalf of the American Thoracic Society, Society of Thoracic Surgeons,
and Society of Thoracic Radiology
THIS OFFICIAL CLINICAL PRACTICE GUIDELINE WAS APPROVED BY THE AMERICAN THORACIC SOCIETY OCTOBER 2018, THE SOCIETY OF THORACIC SURGEONS JUNE
2018, AND THE SOCIETY OF THORACIC RADIOLOGY JULY 2018
Background: This Guideline, a collaborative effort from the MPE; 3) using either an indwelling pleural catheter (IPC) or
American Thoracic Society, Society of Thoracic Surgeons, and chemical pleurodesis in symptomatic patients with MPE and
Society of Thoracic Radiology, aims to provide evidence-based suspected expandable lung; 4) performing large-volume
recommendations to guide contemporary management of patients thoracentesis to assess symptomatic response and lung expansion;
with a malignant pleural effusion (MPE). 5) using either talc poudrage or talc slurry for chemical pleurodesis;
6) using IPC instead of chemical pleurodesis in patients with
Methods: A multidisciplinary panel developed seven questions nonexpandable lung or failed pleurodesis; and 7) treating
using the PICO (Population, Intervention, Comparator, and IPC-associated infections with antibiotics and not removing the
Outcomes) format. The GRADE (Grading of Recommendations, catheter.
Assessment, Development and Evaluation) approach and the Evidence
to Decisi
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