基于顺铂酵母微囊的口服靶向递送系统在治疗肿瘤中的应用研究-药剂学专业论文.docxVIP

优秀毕业论文 精品参考文献资料 第三军医大学硕士学位论文英文缩写词表 第三军医大学硕士学位论文 英文缩写词表 英文缩写 英文全称 中文全称 AAS Atomic Absorption Spectroscopy 原子吸收光谱 ALT Alanine Aminotransferase 谷丙转氨酶 AST Aspartate Transaminase 谷草转氨酶 CBS Carbonate Buffered Saline 碳酸盐缓冲液 CDDP Cis—diamminedichloroplatinum(II) 顺铂 CLSM Confocal Laser Scanning Microscopy 激光共聚焦显微镜 CI也A Creatinine 肌酐 Cy7．5 Cyanine 7．5 花青染料7．5 FDA Food and Drug Aiministration 美国食品药品监督管理局 HE Hematoxylin-Eosin 苏木素．伊红 HGB Hemoglobin 血红蛋白 HPLC High Performance Liquid Chromatography 高效液相色谱 PBS Phosphate Buffered Saline 磷酸盐缓冲液 PDDA-QD Quantum Dots、Ⅳitll Polydiallydimethy- 聚二烯丙基二甲基氯化铵 Lammounium Chloride 修饰的量子点 PEI Polyethyleneimine 聚乙烯亚胺 PLT Platelet 血小板 PreCDDP Cis-[Pt(NHa)2(H20)2](N03)2 顺铂前药 RBC Red Blood Cell 红细胞 SEM Scanning Electron Microscopy 扫描电子显微镜 TEM Transmission Electron Microscopy 透射电子显微镜 TP Total Protein 总蛋白 UA Uric Acid 尿酸 WBC White Blood Cell 白细胞 YC Yeast Capsule 酵母微囊 万方数据 第三军医大学硕士学位论文Eni2inerin 第三军医大学硕士学位论文 Eni2inerin2Enlglnerlng of Osplatin／yeast。platin／yeast capsulepsule}raloral tlellvery system for targeted treatment of cancer Abstract Cisplatin(cis-diamminedichloroplatinum(II)，CDDP)was first approved by the U．S． Food and Drug Adminis似ion(FDA)for the treatment of testicular cancer and bladder cancer in 1 978．Then it has been widely used in clinical practice．As a broad spectrum anticancer drug，cisplatin exerts anticancer effects via multiple mechanisms，yet its most prominent mode of action involves the generation of DNA lesions followed by the activation of the DNA damage response and the induction of mitochondrial apoptosis． Cisplatin has a remarkable effect for varieties of solid tumors，including head，lung， colorectal，breast，ovarian cancer etc．Normally at the beginning of the cisplatin-based treatment of solid tumor，the tumor growth is obviously inhibited and even be significantly decreased．The condition of patients iS also stable．As the treatment continues，finally the majority of patients d