两项依折麦布相关临床试验解读.ppt

Palta S. Circulation 2000;101:2497-502 New insights into the progression of aortic stenosis: implications for secondary prevention. 血浆总胆固醇水平5.2mmol/L者AS进展速率为低胆固醇水平者的2倍。 老年退行性主动脉瓣狭窄与炎症反应相关 Galante A,et al. C-reactive protein is increased in patients with degenerative aortic valvular stenosis. J Am Coll Cardiol 2001:38:1078-82 Ghaisas NK, et al. Adhesion molecules in nonrheumatic aortic valve disease: endothelial expression, serum levels and effects of valve replacement. J Am Coll Cardiol 2000;36:2257-62 正常瓣膜无粘附因子及E-选择素的表达，而细胞间粘附因子-1 （ICAM-1）和血管细胞粘附因子-1（VCAM-1）及E-选择素水平在AS的瓣膜组织中有较高的表达率，分别为75