医学影像配准融合分割技术及其在肺癌精准医疗的应用生物医学工程专业论文.docxVIP

医学影像配准融合分割技术及其在肺癌精准医疗的应用Medical 医学影像配准融合分割技术及其在肺癌精准医疗的应用 Medical Image Techniques Based on Registration，Fusion and Segmentation and its Application in Precision Medicine of Lung Cancer Abstract Precision medicine technology develops rapidly since 2 1 th century and it is officially included in the 1 3th Five．Year Plan．Meanwhile，the advanced medical equipment plays an important role in precision medicine of cancer．The multimodal medical image data captured by medical equipment Can provide clinicians、^，itll more abundant and accurate patient information using modern digital image processing technology．Further,it will contribute significantly to making a precise diagnosis and the treatment plan．This thesis studies the medical image registration，fusion and segmentation，and the research results are applied to the precision medicine of lung CanCer based on PET and CT images．The main work includes： (1)Proposing a novel medical image registration method based on mixed mutual information and improved particle optimizmion algorithm．During each iteration of the proposed algorithm，the improved particle swarm optimization algorithm based on Renyi’S entropy was adopted firstly in global searching phase．Then the mutual information measure based on Shannon’S entropy Was taken as the objective function while the Powell algorithm Was used to obtain the optimal solution in local searching phase．In the experiment of mono·modality and multi·modality medical image registration，the proposed algorithm has the advantage in accuracy and effectiveness．The algorithm is applied to the registration of lung cancer based on PET and CT images，it has better performance on the evaluation of subjective and objective． (2)Proposing a medical image fusion algorithm based on projective dictionary pair learning．For training samples acquired by preprocessing technology，the algorithm will obtain jointly a synthesis dictionary and all analysis dictionary by projective dictionary pair learning and sparse codin