磁共振水脂分离dixon方法在全身脂肪定量中的研究临床医学专业论文.docxVIP

胸廓内脂肪体积多于未绝经组(0．25L 胸廓内脂肪体积多于未绝经组(0．25L VS．0．17L，P=O．009：2．85L VS．2．43L， P=O．068；17．20％VS．13．79％，P=O．71 1)。肝脏脂肪含量、肝脾脂肪含量之比 以及腰椎脂肪含量与血脂各项指标具有相关性，与血胆固醇、甘油三酯、低密度 脂蛋白呈正相关，与高密度脂蛋白呈负相关。腰椎和股骨头的脂肪含量在不同性 别及是否绝经人群中存在差异，男性组的腰椎以及股骨头脂肪分数高于女性组 (92．91％VS．91．08％，P=O．006：93％VS．90．46％，P=O．005)，绝经组的腰椎 和股骨头脂肪分数高于未绝经组(91．66％VS．89．62％，P=O．006：91．78％VS． 87．11％，P=O．005)。多因素二元Logistic回归分析得出，年龄和腹内脂肪体积 是代谢综合征的危险因素。 结论：女性的总体脂肪较男性多，但多分布于躯干部皮下以及双下肢；男性的总 体脂肪少于女性，但易分布于腹腔内。代谢综合征患者的肝脏、胰腺相对脂肪含 量、肝脾脂肪含量比值、腹内脂肪体积及腹内脂肪比例均高于对照组。腹内脂肪 堆积会增加患代谢综合征的风险。 关键词：化学位移成像，Dixon方法，磁共振成像，脂肪定量，代谢综合症 万方数据 Quantification Quantification of whole-body adipose tissue based on magnetic resonance Dixon Technique Abstract Objective：The purpose of the study was to utilize magnetic resonance Dixon Technique to quantify adipose tissue in different human body compartments，and to measure fat fraction of 1iver，spleen，skeletal muscle，and to explore the relationship between fat distribution and disease 1ike hypertension，diabetes，dyslipidemia and metabolic syndrome． Material and method：100 volunteers were recruited and performed whole body scan of Di xon sequence on S i emens MEGNETOM skyra 3．OT scanner． Volunteers received measurements of height， body weight， waist circumference，hip circumference and blood pressure．Body composition was assessed by bioelectrical impedance analysiS．Fasting blood was taken to detect fasting glucose level，glyccosylated hemoglobin，serum Total cholesterol and triglyceride，high—density lipoprotein cholesterol and low-density l ipoprotein cholester01．Software ImageJ was appl ied to measure the volume of intra—thoracic， intra—abdominal，truncal subcutaneous and lower—limb adipose tissue．Software Osirix was utilized to measure fat fract i on of 1 i ver，spl een，pancreas，L2—4 lumbar vertebral body and bilateral femoral heads．Statistical analysiS was as follows： independent t test，Chi—square test and ANOVA test were used to analyze the difference between or among groups．Spearman correlation was used to analyze