阿尔茨海默病人逐体素静息态脑功能异常与相应脑白质异常的相关性分析.pdfVIP

AD showedelevated patients ALFFinleft lobeand temporal rightcingulated FALFFinbilateral cortex(P=0．009，P=0．013)，weakened posteriorcingulated elevatedFALFFinbilateral cortex(P=O．002)and temporal more intheleft prominent side． whitematter wasinvolvedinAD Conclusion：Multipleregions patients，ADC valuewasmoresensitivethanFAvaluefor detectionofAD early patients．Right lobemicrostructureinvolvementis less hasa temporal severe，butstronger with abnormalities．Whitematter Wasmore relationship neuropsychological injury inleft cortical was inleft lobe severitytemporallobe，but activityprior temporal showedelevated functionalMRI in consistently,ADpatients resting-state changes theleft lobe left lobeisthebest temporalconsistently,indicatingtemporal candidate for and ofAD meansof white earlydiagnosisfollow·up patientsby rs-fMRI，and mattermicro-structure andbrain increaseiscausal between injury activity relationship eachotherinAD patients． Words：Alzheimerdiseaserest-statefunctional Key resonance magnetic imaging oflow fluctuationfractionof oflow amplitudefrequency amplitudefrequency fluctuationdiffusiontensor