基于边缘检测算子的Huber正则化阈值选择方法在-南方医科大学学报.PDF

J South Med Univ, 2015, 35(3): 375-379 doi 10.3969/j.issn. 1673-4254.2015.03.12 ·375 · 基础研究 基于基于边缘检测算子的边缘检测算子的HuberHuber 正则化阈值选择方法在低剂量正则化阈值选择方法在低剂量CTCT 重建重建中的应用中的应用 张善立，张 华，胡德斌，曾 栋，边兆英，路利军，马建华，黄 静 南方医科大学生物医学工程学院，广东 广州 510515 摘要：目的研究两种不同的Huber 正则化阈值自适应选取方法及其在低剂量CT 迭代重建中的应用。方法 针对低剂量CT 重 建采用基于Huber 正则化的迭代重建技术，Huber 正则化阈值的选取分别基于全局和局部边缘保持算子。结果 仿真数据的实 验结果表明，两类Huber 正则化阈值自适应选取方法均能较好地抑制重建图像中的噪声和伪影。结论 两类Huber 正则化阈值 自适应选择方法均可实现低剂量CT优质重建。 关键词：低剂量CT ；迭代重建；Huber 正则化；阈值选择 Edge-detecting operator-based selection of Huber regularization threshold for low-dose computed tomography imaging ZHANG Shanli, ZHANG Hua, HU Debin, ZENG Dong, BIAN Zhaoying, LU Lijun, MA Jianhua, HUANG Jing School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China Abstract: Objective To compare two methods for threshold selection in Huber regularization for low-dose computed tomography imaging. Methods Huber regularization-based iterative reconstruction (IR) approach was adopted for low-dose CT image reconstruction and the threshold of Huber regularization was selected based on global versus local edge-detecting operators. Results The experimental results on the simulation data demonstrated that both of the two threshold selection methods in Huber regularization could yield remarkable gains in terms of noise suppression and artifact removal. Conclusion Both of the two methods for threshold selection in Huber regularization can yield high-quality images in low-dose CT image iterative reconstruction. Key words: low-dose CT; iterative reconstruction; Huber regularization; threshold choice 临床X 射线CT检查中的高剂量X 射线照射会引发 息，IR 图像重建模型中需要引入先验信息加以约束，数 白血病、癌症和其他多种遗传性疾病［1］。如何在不影响 学上此约束亦称为正则化（也称为惩罚函数）。通常，正 临床诊断信息的条件下，最大限度地降低CT 放射剂量 则化多设计成一个二次惩罚函数，来惩罚图像某一局部 已成为近年来CT 领域亟待解决的关键性课题。当前， 区域中不同像素点间的灰度差值，其效果是噪声得到抑 诸多策略相继被提出以实现低剂量CT成像［2-3］，其中降