丙泊酚对小鼠小脑皮层分子层和颗粒细胞层感觉信息传递的影响生理学专业论文.docxVIP

延边大学博士学位论文 延边大学博士学位论文 List ofAbbreviations CONTENTS Abbreviations 3 Chapter 1． Propofol modulates sensory information processing in cerebellar molecular layer in vivo in mice． 。4 Abstract 5 1．1 Introduction， 9 1．2 Experimental procedure 1l 1．2．1 Anesthesia and surgical procedures ll 1．2．2 ElectrophysioIogical recordings and drug application ’n 1．2．3 Statistical analysis 11 1-3 Results 12 1．3．1 Effects of propofol on the facial stimulation—evoked field potential responses in cerebellar molecular layer J12 1．3．2 Propofol affected sensory responses via the modulation of GABAA receptor activity、， 1．4 Discussion 一一一 一20 1．4．1 Propofol inhibited the sensory‘stimulation evokes GABAergic component of field potential responses in cerebeHar molecular layer 。～一 ～ 一。20 1．4．2 Propofol enhanced the sensory stimulation evokes excitatory component of field potential responses in cerebeHar molecular layer。、 ～一 1～1—2l 1．43 Propofoi modulated the sensory stimulation-evoked field potential responses in cerebeHar molecular layer via GABAA receptor ·一一22 1．5 Conclusion 一24 References ．25 万方数据 延边大学博士学位论文 延边大学博士学位论文 List ofAbbreviations Chapter 2． Propofol enhances facial stimulation-evoked responses in cerebeilar granule cell layer via activation of NMDA receptor／n vivo in mice 28 Abstract 29 2．1 Introduction 35 2．2 Experimental procedure _38 2．2．1 Anesthesia and surgical procedures 38 2．2．2 Electrophysiological recordings and drug appfication 38 2．2．3 Chemicals 剪 2．2．4 Statistical analysis 一一 - 钞 23 Results ．． 舶 2．3．1 Effects of propofol on the facial stimulation—evoked矗eH potential responses in cerebeilar granule cell layer 40 2．3．2 Blocking GABAA receptor activity failed to prevent the propofoi enhanced facial stimulation-evoked R佣in cerebellar granule cell