基于药物代谢组学的个体化医疗研究进展.PDF

于药物代谢组学的个体化医疗研究进展 1,2 2 3* 黄青 ，阿基业，周国华 （1.中国药科大学，江苏 南京 210009；2.江苏省食品药品监督检验研究院，江 苏 南京 210008；3.南京军区总医院，江苏 南京 210002） 摘要：药物代谢组学作为系统生物学中的新兴学科，近年来逐渐被应用于个体化 医疗并展现出广阔的前景。它通过代谢组学手段，描绘病人个体复杂细致的代谢 轮廓，提供对疾病表型的更加详实的描述，并以 为依据，预测和评估不同个体 对药物的反应能力，从而选择合适的药物和给药剂量，极大地促进了个体化治疗 目标的实现。本文介绍了药物代谢组学这一新兴领域，并对近年来的基于药物代 谢组学的个体化医疗研究成果进行一个详细综述。 关键词：药物代谢组学；代谢组学；个体化医疗；系统生物学；预测 中图分类号：R969 Progressing on personalized medicine using pharmacometabonomics HUANG Qing 1,2 , A Ji-ye 2, ZHOU Guo-hua 3* (1.China Pharmaceutical University, Nanji ng 2 10009, China; 2.Jiangsu Institute for Drug Control, Nanji ng 210008, China; 3. General Hospital of Nanji ng Military Region, Nanji ng 210002, China) Abstract: Pharmacometabonomics, as an emerging branch of systems biology, has been increasingly used in personalized medicine and showed broad prospects. By means of metabonomics, the complicated and detailed metabolic profile of the patient is described, thus providing more detailed description of the disease phenotype. With this understanding, response of different individuals to the drugs are predicted or evaluated through inherent genetic information of the individual combined with the 收稿日期：2014-04-15；修回日期：2014-06-15. * 通讯作者 Tel: 86-25-, E-mail: ghzhou@nju.edu.cn 1 environmental factors. As a result, the appropriate drugs and dosage are chosen, which greatly promotes the realization of the individualized therapy goals. This article describes the emerging field of pharmacometabonomics, and the research results of personalized medicine based on the pharmacometabonomics in recent years are reviewed in detail. Keywords: pharmacometabonomics; metabonomics; personalized medicine; system biology; prediction 1 前言 随着新科学、新技术的发展，人类逐步迈入个体化医疗的新医学时代，通过 针对疾病和病人的具体状态制定出科学合理的个性化治疗方案，使病人得到更加 安全有效的治疗。药物基因组学、药物蛋白组学等的出现，为这一蓝图的