十二指肠空肠旁路术对2型糖尿病肾病大鼠肾功能的影响的研究分析外科学普通外科专业论文.docxVIP

原创性声明本人郑重声明：所呈交的学位论文，是本人在导师的指导下，独 原创性声明 本人郑重声明：所呈交的学位论文，是本人在导师的指导下，独 立进行研究所取得的成果。除文中已经注明引用的内容外，本论文不 包含任何其他个人或集体已经发表或撰写过的科研成果。对本文的研 究做出重要贡献的个人和集体，均已在文中以明确方式标明。本声明 的法律责任由本人承担。 论文作者签名： ——■少——V—一落 日 期： 关于学位论文使用授权的声明 本人完全了解山东大学有关保留、使用学位论文的规定，同意学 校保留或向国家有关部门或机构送交论文的复印件和电子版，允许论 文被查阅和借阅；本人授权山东大学可以将本学位论文的全部或部分 内容编入有关数据库进行检索，可以采用影印、缩印或其他复制手段 保存论文和汇编本学位论文。 (保密论文在解密后应遵守此规定) 论文作者签名：兽缸导师签名：曲细期：地乙 目录 目录 中文摘要······························1 英文摘要·····················-········7 符号说明······························12 第一部分2型糖尿病肾病大鼠模型的建立 前言·······························14日IJ舌 。14 材料和方法 17 结果······························21 讨{念·······························24 结论······························29 附表··················-···········30 附图······························34 参考文献····························39 第二部分十二指肠空肠旁路术对2型糖尿病。肾病大鼠肾功能的影响 前言······························44日U舌 。44 材料和方法 46 结果······························52 讨论······························55 结论······························59 附表······························60 附图······························62 参考文献····························68 致谢································74 攻读学位期间发表的学术论文···························75 英文文章1·····························76 英文文章2·····························96 CATALOGUEAbstract CATALOGUE Abstract in Chinese········································l Abstract in English 7 Symbolic description 12 Part I The establishment of rat models of type 2 diabetic nephropathy Introduction 14 Materials and methods 17 Results······························2l Discussion 24 Conclusion 29 Tables 30 Figures 34 References 39 Part II The effect of duodenal-jejunal bypass on Renal function in a diabetic nephropathy rat model Introduction 44 Materials and methods 46 Results 52 Discussion 55 Conclusion 59 Tables 60 Figures 62 References 68 Acknowledgement 74 List ofpublished papers。 75 English paper l 76 English paper 2 96 山东大学博士学位论文中文摘要 山东大学博士学位论文 中文摘要 第一部分2型糖尿病肾病大鼠模型的建立 背景 在世界范围内，糖尿病发病率呈逐渐上升趋势。其中90％以上是2型糖尿病。 糖尿病肾病(Diabetes