中药提取物6氧当归酰多梗白菜菊素和吴茱萸碱对肺癌治疗作用与分子机理细胞生物学专业论文.docxVIP

AbstractAbstract Abstract Abstract IliiIH Hill[1ili[itm Rllll Y3018617 Worldwide，lung cancer is the incidence and mortality are high；especially in China，the incidence and mortality of lung cancer are the highest in the top class； therefore the urgent need to explore the methods of treatment of lung cancer．Lung cancer is a general designation of lung cancer,but cancer of the lungs Can concrete Can be divided into non small cell lung CanCer(NSCLC)and small cell lung cancer (SCLC)，and non small cell lung cancer and Can be further divided into adenocarcinoma，squamous cell carcinoma and large cell carcinoma，in addition to clinical and divided into 0,I，II，III，IV phase． Lung CanCer is a systemic disease，has complex causes and clinical features，the different types of lung CanCer will require individualized treatment，the main treatment method of radiotherapy and chemotherapy,surgery and in recent years，the 11i91l—speed development of small molecule inhibitors．However,these treatments have certain limitations，SO scientists will look to the magnificent treasure house of traditional Chinese medicine，hope Can from Chinese herbal medicine extract natural compounds in the treatment of lung cancel．This paper mainly includes two aspects： 1．the natural small molecule compounds Centipeda minima effective components of 6—0一angeloylplenolin(6·OAP)on lung cancer cell function，and of epidermal growth factor receptor(EGFR)inhibiting agent gefitinib synergism．Gefitinib is discovered in 1 990 of an epidermal growth factor receptor tyrosine kinase inhibitors (EGFR—TKI)，after the study found gefitinlb Can inhibit lung CanCer cell growth， metastasis and angiogenesis，and induce the apoptosis of tumor cells，applicable in the treatment of previously received chemotherapy for locally advanced and metastatic non small cell lung cancer．Laboratory studies have found that the molecular mechanism of 6-OAP targeted SCF complex induces cell cycle G2／M arrest，and has the Pharmacokinetic characteristics．Fu