药物干预低促性腺激素性闭经致不孕的临床研究-中国药房.PDFVIP

药物干预低促性腺激素性闭经致不孕的临床研究 ＊ # 杨 广 ，罗汝琼（攀枝花市妇幼保健院药剂科，四川攀枝花 617000） + 中图分类号 Q575.12；R711.6 文献标志码 A 文章编号 1001-0408（2015）20-2813-03 DOI 10.6039/j.issn.1001-0408.2015.20.27 摘 要 目的：探讨药物干预对低促性腺激素性闭经所致不孕症的临床治疗作用。方法：将低促性腺激素性闭经所致不孕患者 33例作为研究对象，采用人工月经周期+尿促性腺激素+人绒毛膜促性腺激素（HCG ）进行治疗，观察临床疗效。结果：33例患者总 计35个促排卵治疗周期。治疗后妊娠者有19例，卵泡发育超成熟者有5例（成熟卵泡＞3个，放弃HCG 治疗与妊娠计划），卵泡发 育成熟者有6例（未能妊娠成功），剩余3例为促卵泡发育失败。结论：采用外源性促性腺激素治疗低促性腺激素性闭经所致不孕症 可以取得良好的疗效，但需合理掌握用量，以避免对卵泡质量造成影响。 关键词 不孕；低促性腺激素性闭经；人工月经周期；尿促性腺激素；人绒毛膜促性腺激素 Clinical Study of Drug Intervention for Hypogonadotropic Amenorrhea-induced Infertility YANG Guang ，LUO Ru-qiong （Dept. of Pharmacy ，Panzhihua Maternal and Child Care Service Centre ，Sichuan Panzhihua 617000，China ） ABSTRACT OBJECTIVE ：To explore the clinical efficacy of drug intervention on hypogonadotropic amenorrhea-induced infertili- ty. METHODS ：33 patients with hypogonadotropic amenorrhea-induced infertility were included in study ，and then received artifi- cial menstrual cycle+HMG+HCG. Therapeutic efficacy was observed. RESULTS ：33patients were included in the study ，involving a total of 35ovulation induction cycles. After treatment ，there were 19cases of pregnancy ，5cases of follicular development （more than 3mature follicle ，giving up HCG treatment and pregnancy plan ），6 cases of follicular development （pregnancy failure ）and 3 case of follicular development failure. CONCLUSIONS ：Exogenous gonadotropin obtain relatively good results in the treatment of hypogonadotropic amenorrhea-induced infertility ；but we must pay attention to drug dose so as not to affect the quality of folliculus. KEYWORDS Infertility ；Hypogonadotropic amenorrhea ；Artificial menstrual cycle ；HMG ；HCG 与选择的患者有关，入选患者均神志清醒、能够配合、有咳嗽 进展[J].护理研究，2011，25（11）：2930. 能力。但在实施过程中相应负责人应严格进行方案执行的过