cmi2014-chapter-8-ly前mphocytedevelopmentppt课件.ppt

4. Survival and maturation of lymphocytes in peripheral lymphoid tissues.外周淋巴组织中淋巴细胞的生存和发育 * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-23 不同淋巴细胞定位于外周组织的不同部位. 淋巴结的滤泡及生发中心(Germinal center)为B细胞区 淋巴结的T细胞区 * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-24 外周淋巴样组织的发育受淋巴样组织诱导细胞和TNF家族蛋白所调控. * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-25 淋巴细胞归巢（homing）至特定淋巴样组织是由趋化因子所介导. * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-26 淋巴细胞在外周首次遭遇足够量自身抗原时被删去或灭活. 外周耐受的形成机制: deletion、anergy 活化诱导的细胞死亡 (activation-induced cell death, AICD) * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-27 到达脾脏的B细胞快速更新，其成熟和存活需接受BCR和细胞因子信号. * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-28 B-1细胞和边缘区B细胞是一类具有独特抗原特异性受体的B细胞. * Survival and maturation of lymphocytes in peripheral lymphoid tissues. 8-29 外周T细胞的自稳受细胞因子和自身MHC调控. IL-7 MHC interaction * Thanks The end of chapter 8 * * Cellular and Molecular Immunology Xian-Hui He Department of Immunobiology Jinan University 2014-11 * Chapter 8 The Development and Survival of Lymphocytes Development of B lymphocytes. The development of T lymphocytes in the thymus. Positive and negative selection of T cells. Survival and maturation of lymphocytes in peripheral lymphoid tissues. Part III The development of mature lymphocyte receptor repertoires * 中枢耐受的形成 1. Development of B lymphocytes. B淋巴细胞的发育 * Development of B lymphocytes. 8-1 B淋巴细胞由骨髓中的造血干细胞 (HSC) 所产生. hematopoietic stem cells (HSC) . 骨髓中产生BCR 骨髓中阴性选择 在外周活化 成为浆细胞和记忆细胞 * Development of B lymphocytes. B细胞早期发育依赖于骨髓基质细胞 (stromal cells) . 骨髓基质细胞表达B细胞发育所需的IL-7、CXCL12、VCAM-1、SCF * 晚期祖B细胞 多能干细胞 前B细胞 未成熟B细胞 早期祖B细胞 淋巴样干细胞 Development of B lymphocytes. 8-2 B细胞发育始于重链基因的重排, 重链与替代轻链组成前B受体 (Pre-B receptor). * 大前B细胞 多能干细胞 小前B细胞 未成熟B细胞 晚期祖B细胞 早期祖B细胞 成熟B细胞 重链重排 前B受体 轻链重排 IgM表达 IgD表达 Development of B lymphocytes. 8-3 前B受体检