复方猫乳散对高尿酸血症及痛风性关节炎模型的主要药效学及部份机理研究中药学专业论文.docxVIP

成都中医药大学博士论文神经递质以及其抗炎、镇痛作用有关。 成都中医药大学博士论文 神经递质以及其抗炎、镇痛作用有关。 本课题首次从该处方中筛选出猫乳、乳香有良好的降血尿酸作用，属 该药新功效的创新发现。对此发现可拓展该药的临床应用，为临床研制出 更为安全、有效的防治高尿酸血症及抗痛风药物奠定了良好的基础。对发 展该类中药的功效理论具有一定的学术价值和临床意义。 本课题首次对该方进行了初步的拆方研究，以期筛选出降血尿酸和抗 痛风更为有效的药物或最佳的药物组合。 关键词：复方猫乳散高尿酸血症痛风 成都中医药大学博士论文ABSTRACT 成都中医药大学博士论文 ABSTRACT The compound Maoru po、砌er、Ⅳas choosed to treat h)，pemricaemia arld gouty一甜hritis from a great deal of Tibetan prcrved rccipes for the first time under the guidaIlce of TCM aIld Tibetan medicine theoU n was origiml for there were no similar dmgs in the market． This reseal℃h concluded of chief pbanllacology experiments aIld mechanism study．The results showed： 1．It could reduce the uric acid of hyp咖ricaemia animal model and inhibit xallmenes oxidation enzyme(XOD)． 2． It couId markedly relieve the swollen foot of animal model of gouty_artllritis，reduce tlle content of TNF—Q、IL一1 B、IL一6 in ankle joim， increase the content of 5．Hrr and DA in neⅣe cen订e and reduce the content of 5．HT a11d DA in blood semm． 3．It could崩narkablv decrease the twist—reaction stimulated bv acetic acid， eIlllance the口ain threshold incluced bv heat irritation． 4，It could restrain也e infl枷ation induced by eg窟white，dimethylbenzen， and tampon．AU the results indicated mat it h砸good effects on gou讳artb—tis and h、币emricaemia．Its treatment of hypemricaemia had something to do wim d印ressin窟XOD．The mechanism of anti—gout was decreasing the content of TNF—cc、 IL．1 B IL．6 in ankle ioim． ns efrects of abinjtation and anti．innammation was owing to ad{usting the contcnt 0f 5．HT and DA． Maom and RuxiaIlg are discovered for the nrst time that it has good e航ct of lowedng uric acid，which is original found of its如nction．With its f11nher clinical application，it could developed into new dmg to cure hypemricaemia and gouty—ar岫吼is aIld had academic value for mis kind of Chinese medicine to deVelop meir mnction meo醪 Taking apart experiment of Maoru Powder was done for the first time to find more e饪．ective dnjgs or more ef毪ctive combinat