胃癌患者近远期预后影响因素的COX模型分析-中华普通外科学文献.PDFVIP

· 2 0 9 · 中华普通外科学文献（电子版）2014 年 6 月第 8 卷第 3 期 Chin Arch Gen Surg（Electronic Edition)，June 2014，Vol.8，No.3 ·论著 · 胃癌患者近远期预后影响因素的 COX 模型分析 杨志锋　江小梅 　　 【摘要】　目的　探讨影响胃癌预后的主要因素 。方法　选择中山市人民医院普外三科 2005 年 12 月至 2008 年 12 月收治的 160 例胃癌患者，采用 COX 回归模型，将患者的临床资料和随访情 况作为分析因子计算生存率，多因素回归分析预后影响因素 。结果　总随访率 93.75 %（150/160）， 截至 2013 年 1 月存活 53 例，总 1、3、5 年累计生存率分别为 66.70 %、50.67 %、38.67 %。单因素 分析表明胃癌预后与手术方式、肿瘤大体分型、组织分型、浸润深度、淋巴结转移情况及 TNM 分 期有关（P 0.05）。COX 多因素分析结果显示手术方式、肿瘤大体分型、组织分型、浸润深度、 淋巴结转移情况及 TNM 分期是胃癌预后的独立预后因素（P 0.05）。Borrmman 分型与远期预后相关， 而与近期预后无关。综合治疗与近期预后有关，与远期预后无关。结论　手术方式、肿瘤大体分型、 组织分型、浸润深度、淋巴结转移情况及 TNM 分期是胃癌预后的独立预后因素 。 　　 【关键词】　胃癌；预后；影响因素；COX 模型 Multivariate analysis of short and long term prognostic factors for gastric cancer Yang Zhifeng, Jiang Xiaomei. Department of General Surgery, Zhongshan City Peoples Hospital, Zhongshan 528403, China Corresponding author: Yang Zhifeng, Email: yangzhifeng.007@163.com 　　【Abstract】　Objective　To investigate the major influences of the gastric cancer prognosis. Methods　Prognostic factors of the gastric cancer were analyzed by Cox multivariate regression model based on clinical data of 160 cases with gastric cancer in the Third Department of General Surgery of Zhongshan City Peoples Hospital from December 2005 to December 2008. And the survival rates were calculated. Results　Until January 2013, 150 cases (93.75 %) were followed up with 53 survived, the overall survival rate for 1-, 3-, 5-year was 66.70 %, 50.67 %, 38.67 % respectively. Univariate analysis indicated that the operation type, tumor gross subtypes, histological subtypes, invasion depth, lymph node metastasis and TNM stage were found to be significantly associated with the prognosis of the gastric cancer (P 0.05). Cox multivariate analysis illustrated the operation type, tumor gross subtypes, histological subtypes, invasion depth, lym