高原低氧影响药物代谢的研究与进展-药学学报.PDF

原低氧影响药物代谢的研究与进展 1 2 * 张娟玲 ，李向阳 （1.青海大学生态环境工程学院，青海 西宁 810016 ；2. 青海大学医学院，青海 西宁 810001 ） 摘要：高原具有低氧、低压、强辐射、寒冷、干燥等环境特征，其中低氧是影响 人体正常生命活动的主要因素，研究高原低氧条件下的药物代谢特征对于了解药物在 高原机体的代谢和消除快慢并指导高原地区临床合理用药具有重要意义。本文综述了 高原低氧对药物代谢的影响，阐述了高原低氧条件下部分药物的代谢特征及药物代谢 酶活性和表达的变化，并探讨了相关机理。 关键词：高原；低氧；药物代谢动力学；药物代谢酶 中图分类号：R969 文献标识码： 文章编号： A review of drug metabolism under hypoxia environment at high altitude 1 2 ﹡ ZHANG Juan-ling , LI Xiang-yang (1. College of Ecological and Environment Engineering, Qinghai University, Xining 810016, China; 2. Medical College, Qinghai University, Xining 810001, China) Abstract: The special environmental features of high altitude, such as hypobaric hypoxia, low temperature, arid, high solar radiation, variable climate and geochemical anomaly, cause great effects on human physiology and health. It will provide valuable references and new ideas to study drug s metabolism in special environment of high altitude hypoxia, and give the guidance to clinical reasonable medication, avoiding adverse reactions and personalized medicine in plateau areas. This article reviewed the effect of high altitude hypoxia on drug metabolism, elaborated metabolic characteristics of some drugs and the activity and expression of drug metabolism enzymes under hypoxia environment at high altitude, and discussed the related mechanism. Key words: high altitude; hypoxia; pharmacokinetics; drug metabolism enzyme 收稿日期：2015-01-30; 修回日期：2015-04-07. 基金项目：国家自然科学基金项目 ）；教育部新世纪优秀人才支持计划 (NCET-10-0917). * 通讯作者 Tel: 86-971-5362082, Fax: 86-971-5362383, E-mail: qhmclxy@163.com