胆管纳米银涂层抗菌塑料支架的研制.PDF

Chinese Journal of Medical Instrumentation 2011 年35 卷第5 期 研 究 与 论 著 文章编号：1671-7104(2011)05-0352-04 胆管纳米银涂层抗菌塑料支架的研制 杨杰1 1 2 【作 者】 ，令狐恩强 ，王银川 1 解放军总医院消化疾病中心 ，北京 ，100853 2 北京大学化学与分子工程学院，北京，100871 【摘 要】胆管塑料支架置入胆管时常见的并发症是胆管炎、支架阻塞，可以见到大量的细菌菌落。应用低浓度的银离子对细菌、真 菌等微生物具有杀灭作用。通过化学氧化还原法，以胆管塑料支架为载体，硝酸银为原料，在胆管支架内外表面均匀沉积 纳米银，研制成功纳米银涂层抗菌塑料胆管支架。通过扫描电镜 （SEM ）、透射电镜 （TEM ）、X射线能谱分析(EDXA)、 扫描隧道显微镜 （STM ）等检测纳米银涂层塑料胆管支架的弹性系数和摩擦系数。结果表明，制备纳米银涂层纳米颗粒分 布均匀、纯度高、纳米颗粒大小约5-80 nm。纳米银涂层抗菌塑料支架表面光滑，弹性较原始支架无明显变化。 【关 键 词】纳米银；抗菌 ；胆管支架 【中图分类号】TH789 【文献标志码】A doi:10.3969/j .issn.1671-7104.2011.05.009 Development of Antibacterial Plastic Biliary Stent Coated with Nono-Silver 【Writers 】 1 1 2 Yang Jie , Linghu Enqiang , Wang Yinchuan 1 Department of Gastroenterology and Hepatology, Chinese People s Liberation Army General Hospital, Beijing 100853, China ’ 2 College of Chemistry and Molecular Engineering, Peking University, Beij ing 100871, China 【Abstract 】The common complications of the endoprosthesis are occlusion of the stents, and cholangitis. There are many bacterial colonies in the blocked stents. Some studies have proved that the silver in a low concentration has the antimicrobial efficacy .The plastic biliary stents coated with nano-silver were prepared by the chemical redox process with plastic stents as carriers and silver nitrate as material. Then the friction coefficient and elastic modulus of the stents were detected by use of scanning electron microscope(SEM),transmission ele