聚合物修饰的金纳米粒在癌症治疗中的研究进展Polymer.pdfVIP

药学学报 Acta Pharmaceutica Sinica 20 16, 51 (2): 281 286 ·281 · 合物修饰的金纳米粒在癌症治疗中的研究进展 1, 3 2 1* 1, 3* 腾 , 洪 瑾 , 丁 娅 , 张 灿 ( 中国 科大学 1. 物质量与安全预警教育部重点实验室, 江苏 南京 2 10009, 2. 理学院医药生物功能材料重点实验室, 江苏 南京 2 11198, 3. 物科学研究院, 江苏 南京 2 10009) 摘要: 聚合物修饰的金纳米粒具有稳定性好、生物相容性高和体内外毒性小等优点, 可用来作为或构建多种 试剂或载体用于癌症治疗, 在生物医学领域受到广泛关注。本文综 了近年来聚合物修饰的金纳米粒在癌症治 疗方面的研究进展。 关键词: 聚合物; 金纳米粒; 癌症治疗; 基因; 免疫 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (20 16) 02-0281-06 Polymer-modified gold nanoparticles for cancer therapy 1, 3 2 1* 1, 3* CUI Teng , HONG Jin , DING Ya , ZHANG Can (1. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanj ing 210009, China; 2. Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing 211198, China; 3. Center of Drug Discovery, China Pharmaceutical University, Nanj ing 210009, China ) Abstract : Polymer-modified gold nanoparticles, which are more stable, less toxic to human body and have improved biocompatibility, have received intensive attention in biomedical applications, which can be used as or construct various therapy agents or carriers in cancer treatment. This review summarizes the current investigation of polymer-modified gold nanoparticles on their cancer treatment applications. Key words: polymer; gold nanoparticle; cancer therapy; gene; immunity 金纳米粒 (gold nanoparticles, GNPs) 是一类纳 合物对GNPs 进行表面修饰, 利用修