基于功能化模板的胶束增强型聚电解质胶囊的研究-材料学专业论文.docx

摘 摘 要 高，但是载药量较低。当被包埋物带强的正电荷时往往导致胶囊的载药量大大增 加，但是也导致胶囊总的药物释放率过低。试验还发现，胶囊对于牛血清蛋白 (BSA)具有较好的缓释作用。这种聚电解质胶囊的囊壁的双层结构是影响其包 埋物释放速度的关键因素，同时，被包埋物的分子量和电荷性能也强烈的影响了 胶囊的释放行为。 关键词：功能型模板，杂化碳酸钙微球，聚电解质胶囊，LBL技术，诱导沉积、 大分子胶束 Ⅱ 浙江大学博士学位论文(2006)Study 浙江大学博士学位论文(2006) Study of NovelMieeHes-Enhaneed”to,electrode Microcapsules Based帆Functional Templates Abstract Layer-by-layer(LaL)assembly of oppositely charged polyelec血olytes onto removable colloidal particles might be the most widely employed technique to prelgare novel hollow nano-and microcapsules．This fabrication technique allows control of the capsule size and shape，the capsule wall thickness,and the capsule wall composition．Microcapsules with versatile properties can be obtained by introducing one or more functional components such as nanoparticles,biomacromolecules，llpids， photosensitive dyes，inorganic crystals，and multivalant ions onto the capsule wall or into the capsule interior．However,it is difficult for polyelectrolyte capsule to encapsulate water-soluble substances due to high permeability ofthe capsule shell．In this paper,a novel hybrid calcium carbonate microparticle Was synthesized to sa*ve as template to fabricate polyelectrolyte capsule by LBL technique．ARer the templates were removed，the capsule shell Was tailored by the substances in template which was intentionally retained in capsule．At the same time,the retained substances serve as a driving force to entrap water-soluble substances into capsule interior with high efficiency．The novel hybrid template Was named as functional template． Hybrid calcium carbonate microparticles were synthesized in the presence of block copolymer PS-b-PAA which served as three·dimensional templates．R’S found that the PS—b-PAA based micelles can form spheric shape network in the presence of calcium ions as templates to control the morphology ofhybrid calcium carbonate．The direct proofs Were obtained through TEM．Surprisingly enough,the hybrid particles have strongly acid resistant properties．