基于炎症环境的口服结肠靶向给药系统研究进展.PDFVIP

基于炎症环境的口服结肠靶向给药系统研究进展 * 肖健，黄仁杰(福建卫生职业技术学院药学系，福州 350101)  摘要： 口服结肠靶向给药系统由于能改善结肠局部疾病的治疗效果和降低不良反应而成为该领域的研究热点。口服给药 系统设计方法的不断发展显著提高了药物在结肠部位的生物利用度，然而，要使药物在发病期能够发挥治疗效果，还须 关注到结肠炎症时胃肠道出现生理条件变化的影响。纳米技术已经作为提高药物在结肠炎症病灶区摄取的新策略而应用 于口服剂型设计中，本文主要介绍该纳米给药系统的设计方法和研究进展。 关键词：结肠靶向给药系统；口服给药；纳米技术；炎症性肠病 中图分类号：R943 文献标志码：A 文章编号：1007-7693(2017)06-0928-05 DOI: 10.13748/ki.issn1007-7693.2017.06.031 引用本文：肖健, 黄仁杰. 基于炎症环境的口服结肠靶向给药系统研究进展[J]. 中国现代应用药学, 2017, 34(6): 928-932. Advances in Oral Colon Targeted Drug Delivery System Based on Inflammation * XIAO Jian, HUANG Renjie (Department of Pharmacy, Fujian Health College, Fuzhou 350101, China) ABSTRACT: Oral colon targeted drug delivery is an active area of research for local diseases affecting the colon, as it improves the efficacy of therapeutics and reduces systemic toxicity. Advances in oral drug delivery design have significantly improved the bioavailability of drugs to the colon; however in order to have therapeutic efficacy for a drug during disease, considerations must be made for the altered physiology of the gastrointestinal (GI) tract that is associated with GI inflammation. Nanotechnology has been used in oral dosage formulation design as strategies to further enhance uptake into diseased tissue within the colon. This review will summarize the major design methods of nano-delivery systems and the research progress. KEY WORDS: colon targeted drug delivery system; oral administration; nanotechnology; inflammatory bowel disease 口服结肠靶向给药系统(oral colon targeted 个体因素的影响较大，普遍存在体内靶向性较差 drug delivery system，OCDDS)是指通过药物传递 或者吸收差等问题。特别是伴有结肠炎症患者的 技术，使药物口服后在胃、十二指肠、空肠、回 肠道 pH 值、转运时间、肠道菌群、肠液容积、肠 肠前端不释放药物，将药物运送到回盲部后释放 黏膜完整性等生理条件均可能发生显著的改变[3] 。 而发挥局部或全身治疗作用的一种新型定位给药 这不仅会导致药物在肠道转运规律发生变化，还 系统。在临床上可用于治疗肠