甲状腺功能亢进对肝功能的影响及中药甲亢宁对其干预的研究-中医内科学专业论文.docxVIP

提 提 要 目的：探讨甲状腺功能亢进患者对肝功能的影响以及中药甲亢宁对甲亢性肝损 伤的防治作用。方法：1．相关性研究：对162例甲亢患者的甲状腺功能及肝功能 进行观察，以观察随着甲状腺激素水平的升高，患者肝功能的变化情况，探讨改善 甲状腺功能对于防治甲亢性肝损伤的意义；2．干预研究：将已确诊甲亢性肝损伤 患者随机分为治疗组和对照组各30例，其中治疗组给予中药甲亢宁，对照组给予 丙基硫氧嘧啶和肌苷，两组疗程均为2个月，治疗前后分别观察和测定甲状腺功能 (T3、T4、TSH、FT3、FT4)、血脂、肝功(ALT、AST、ALP)和血B 2一微球蛋 白等指标。结果：1．相关性研究结果：通过对162例患者观察所得，共有68例患 者合并肝损伤。各项数据分析比较表明，甲亢患者肝损伤的发生与年龄、病程呈正 相关，与性别无显著性差异。甲亢性肝损伤与患者甲功、基础代谢率、血02一微球 蛋白呈正相关。2．干预研究结果：经用甲亢宁治疗两个月后结果表明：甲亢宁不 仅可以有效改善甲亢性肝损伤患者的症状体征，而且能够显著改善甲亢性肝损伤患 者的甲状腺功能异常，同时具有改善患者肝功能异常和改善血脂的作用，且无毒副 作用。经30例临床观察证实有效率达86．7％，明显高于对照组。结论：1．甲状腺 功能亢进与肝损伤关系密切；2．改善甲状腺功能对甲亢性肝损伤患者具有重要意 义：3．甲亢宁可以有效改善甲亢性肝损伤患者的甲状腺功能和肝功能，为治疗甲 亢性肝损伤的有效中成药。 关键词甲亢宁：甲亢性肝损伤；干预研究 未经作者、导师同蠢 ■全文公布 Clinical Clinical Study on the Correlation of Hepatic Dysfunction and Hyperthyroidism Speciality：Medicine ofTCM‘The prevention and treatment ofendocrine diseases Author：Xin Yan Tutor：ProE Qian Qiuhai Abstract Objective：To explore the relation between hyperthyroidism and hepatic dysfunction and lo study the prophylaxis and treatment ofhyperthyroidism hepatic dysfunction with Jia Kang Ning． Methods：1．T3、T4、TSH、FT3、FT4、ALT、AST、ALP、A、A／G of 162 hyperthyroidism patients were determined and analyzed．2．Randomly，60 hyperthyroidism hepatic dysfunction patients were divided into observation group and control group．The observation group patients were treated by Jia Kang Ning，and the control group patients were treated by Propylthiouracil and Jigan．After 2 months，the experimental indexs(T3、 T4、TSH、FT3、FT4、TC、TG、ALT、AST、ALP、were compared to those in the beginning Result：1，T3、T4、FT3、FT4、ALT、AST、ALPwere significantly higherthanthat of the group without hepatic dysfunction．2 The total effectiveness rate of the Jia Kang Ning group is 86 7％，whereas that of the control group is merely 56．7％，after processed with statistical methods，there is significant difference．Jia Kang Ning can improve the clinical symptoms and paysical signs of hyperthyroidism hepatic dysfunction and improve thyroid function and hepatic function markedly．Conclusio