高效压片机对粉末直压技术的诠释.pptxVIP

;Content FETTE Compacting——your reliable partner FETTE是可以信赖的伙伴 Direct compression differences to granule compression 直接压片与制粒压片的区别 Compacting process 压片工艺 Direct compression advantages and difficulty 直接压片的优势和难点 How to solve this problem 如何解决这个问题;Direct compression differences to the Granule compression 直接压片与颗粒压片的区别 Particle size not homogeneous 颗粒不均匀 Particle size smaller than granulated powder 粒径小于制粒后的颗粒 binding problems 粘合性问题 Bad compressibility 可压性差 Different densities possible 密度差 Filling problems under high speed conditions 在高速旋转状态下填料不充分 Bad flow characteristic 流动性差;Compacting process 压片工艺 Under high pressure smaller particles move to interstices of the larger particles 在高压片力下，小颗粒嵌入到大颗粒中 Slip off and plastic deformation of the primary and secondary particles 产生塑性变形 Formation of new contact surfaces 形成新的接触表面;Advantages of the direct compression 直接压片的优势 No granulation process necessary 不需要制粒过程 Saves time and money 节省时间和金钱 Reduced process and handling costs 减少物料损耗，增加产品收率;;Dry Granules Process 干法制粒工艺;Difficulty and problem of the direct compression 直接压片的难点和问题 Bad flow characteristic of the powder 物料流动性差 Segregation (demixing) in the feed hopper or transport bins 在料斗或上料装置中出现分层现象 Difficult handling and compacting of the powder 可压性差;Difficulty and problem of the direct compression 直接压片的难点和问题 Powder bridges in the feed hopper and in the product pipes 在料斗中出现架桥现象 High risk of capping of the tablets 顶裂现象 High risk of sticking during compressing 粘冲现象 Compressing process can only run under lower speed in comparison to granulated powder 与颗粒压片相比，压片机仅能运行较低速度;Solutions to bad compressibility 可压性差解决方案 Step 1: Tablet Capping because of bad Compressibility and low bulk density 粉末可压性差，低密度产生顶裂;Solutions to bad compressibility 可压性差解决方案 Solution 1: The Same diameter between pre-compression roller and main-compression roller 相同直径的预压、主压最大可产生100KN压力 Why: the sufficient air exhaust in pre-compression process is very important prevent capping!!! 在预压过程中的充分排气对于防止顶裂具有至关重要作 用;Solution 2: Tap