课件：溶血性贫血的介绍.ppt

WWW Sites of Interest Anemias: /classware/pathology/Krause/Anemias/Anemias.html (Overview of anemias from Dr. John Krause’s Hematopathology Homepage, Tulane University-link provided) 资料可以编辑修改使用 学习愉快！ 课件仅供参考哦， 实际情况要实际分析哈！ 感谢您的观看 骨髓具有正常造血6~8倍的代偿能力。 EnzymopathiesHemolytic Anemia Laboratory findings: G6PD deficiency Bite cells Heinz bodies Spot test: Strong flourescence indicates normal G6PD activity Bite CellsMorphology Pathophysiology Cratered RBC Craters formed by removal of Heinz bodiesformed from unstable hemoglobin EnzymopathiesHemolytic Anemia Slides not shown. See Figure 17-6, p. 262, Clinical Hematology EnzymopathiesHemolytic Anemia Laboratory findings: PK deficiency Spot test: Loss of flourescence indicates normal PK activity Plasma Constituent Abnormalities Abetalipoproteinemia: AKA hereditary acanthocytosis Lecithin-Cholesterol Acyltransferase Deficiency: Numerous target cells Target Cell (Codocyte) Pathophysiology Increased cholesterol or phospholipid onRBC membrane Increased surface area:volume Pre-crystalline state of hemoglobin C Target Cell (Codocyte) Slides not shown. See Figure 8-11, p. 92, Clinical Hematology Echinocyte Morphology 30 short, blunt projections evenly distributed over the cell surface A.K.A. burr cell, crenated RBC sea urchin cell Wet mount comparison Acanthocyte Morphology 5-12 thornlike spicules unevenly distributed over the cell surface Projections may be club shaped or drumstick shaped (spur cells) Acquired Hemolytic Anemia Extracorpuscular defects Abnormal blood vessel structure Mechanical injury Miscellaneous Intracorpuscular defects Immune processes Extracorpuscular Defects Microangiopathic hemolytic anemia Disseminated intravascular coagulation (DIC) Hemolytic uremic syndrome (HUS) Thrombotic thrombocytopenic purpura (TTP) Direction of blood flow Fibrin SchistocyteMicroangiopathic Trauma SchistocyteMicroangiopathic Trauma Slides not shown. See Figure 8-12, p. 94, Clinical Hematology Intracorpusc