金属镱及二碘化钐促进的有机反应在有机合成中的应用-应用化学专业论文.docxVIP

晰江工土上学嘎士学位论文摘 晰江工土上学嘎士学位论文 摘 要 本论文共分为两章：1．金属镱促进的有机反应在有机合成中的应用；2．二碘 化钐促进的有机反应在有机合成中的应用。 第一章，首先我们综述了近几年来金属镱促进的有机反应在有机合成中的应 用。然后研究了金属镱使二芳酮的极性反转，从亲电试剂转变为亲核试剂，形成 较稳定的镱(II)一二芳酮三元环中间体与亲电试剂亚胺发生的亲核加成反应，以 及与胺基烷基苯并三氮唑发生的亲核取代反应，一步高产率的合成了芦一胺基醇 类化合物；还研究了金属镱促进口．口一不饱和二腈及口，口一不饱和腈酯的还原二 聚环化反应，一步高产率、立体选择性的得到了官能化的环戊烯胺类衍生物。 第二章，首先我们综述了近几年来二碘化钐促进的有机反应在有机合成中的 应用。然后研究了二碘化钐促进氯甲基苯并三氮唑与异氰酸酯的偶联反应，首次 合成了N一取代一2一苯并三氮唑乙酰胺类化合物；还研究了二碘化钐对邻叠氮基苯 甲酰胺及邻叠氮基苯磺酰胺的还原，得到的活性中间体进一步与醛酮进行的环化 反应，分别一步高产率的合成了2，3一二氢喹唑啉酮类衍生物和3，4一二氢一(2均一l， 2，4一苯并嚷二嗪-I，1一二氧化物。 以上所研究的反应具有原料易得、操作简便、反应条件温和、中性、立体选 择性、产率较高以及原子经济性等优点。 浙江工业土霹硕士学谯论文AB鲥RACT 浙江工业土霹硕士学谯论文 AB鲥RACT This镬sserration consisted of two chapters．‘I’he first one is岛eused on metallic ytterbium promoted organic reactions and their applications in organic synthesis、The second is focused Oil samarium diiodide promoted organic reactions and their applications in organic synthesis． 融chapter one,at first,We simply outlined Some reactions promoted by metallic ytterbiam in recent years．And then nucleophilie addition of metallic ytterbium umpoled diaryl ketones to imines and nucleopbJlie substitution reactions of aminoalk3tIbenzotriazoles with metallic ytterbium umpoled diaryl ketones were studied respectively．露一amino alcohols懿豫pmpared in g淡匹yields under mild and neutral conditions．A novel cyelodimefzation of arylmethylidenemalonortitriles and arylmethylenecyanoaeetates promoted bY metallic ytterbiumteas also investigated and蛐functionalizcd cyclopentene derivatives were obtained． In chapter tWO,firsfly’some ma蕊om promoted by samarium diiodide in recent years Were simply omlined．The CROSS coupling of cblommethylbenzolriazole and isocyanates promoted by samarium diiodideⅥ7as then studied and N-substituted-2-(benzotriazol·1-y1)ao耸laraidcs were l融stly obtained in good yields under very mild and neutral conditions．In addition,雠also found that } o-azidobenzeamides and o-azidobenzenesulfonaraides could be reduced by samarium diiodide to produce the active intermediates,which reac