内分泌治疗新思考.pptVIP

Thank you！ * * The classic mechanism of action of the ER is its nuclear function (also referred to as the genomic activity of the ER) consisting in the regulation of the expression of genes important for normal cell function but also tumor growth and survival. In addition to ER-mediated signaling, other growth factor-mediated signaling pathways also play a role in advanced breast cancer. There is crosstalk between the ER-mediated signaling pathway and other growth factor-mediated signaling pathways. The activation of the ER by growth factor-mediated signaling pathways is referred to as ligand-