小分子生物硫醇荧光探针研究进展_王胜清.pdfVIP

DOI: 10.6023/cjoc201403030 Chinese Journal of Organic Chemistry REVIEW * ( 250100) (Cys)(Hcy)(GSH). , , . , , . ; ; ; ; ; Recent Progress in Fluorescent Probes for the Detection of Biothiols Wang, Shengqing Shen, Shili Zhang, Yanru Dai, Xi Zhao, Baoxiang* (Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100) Abstract Intracellular thiols, such as cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play crucial roles in main- taining biological systems. In last decade, developing small molecule probes for selective and sensitive detection of thiols un- der physiological conditions have attracted great interest. Fluorescent and colorimetric sensors are classified into two types of reactions according to their mechanism of reaction with thiols, including the reaction with mercapto group, the reaction with mercapto and amino group. Therefore, in this review we provide a general overview of the selected recent research involving the design and application of biological thiol-selective chemosensors. Keywords fluorescence; probe; glutathione; homocysteine; cysteine; thiol (Cys)(Hcy) . (GSH) , [18] . , , , . . , , . [911]. [ 2031]pH[3239], , ,