Natural products-An evolving role in future drug discovery英文文献资料.PDFVIP

European Journal of Medicinal Chemistry xxx (2011) 1e39 Contents lists available at ScienceDirect European Journal of Medicinal Chemistry journal homepage: http://www.el /locate/ejmech Mini-review Natural products: An evolving role in future drug discovery Bhuwan B. Mishra, Vinod K. Tiwari* Department of Chemistry, Centre of Advanced Study, Banaras Hindu University, Varanasi 221005, India a r t i c l e i n f o a b s t r a c t Article history: The therapeutic areas of infectious diseases and oncology have benefited from abundant scaffold diversity Received 7 June 2011 in natural products, able to interact with many specific targets within the cell and indeed for many years Received in revised form have been source or inspiration for the majority of FDA approved drugs. The present review describes 29 July 2011 natural products (NPs), semi-synthetic NPs and NP-derived compounds that have undergone clinical Accepted 30 July 2011 Available online xxx evaluation or registration from 2005 to 2010 by disease area i.e. infectious (bacterial, fungal, parasitic and viral), immunological, cardiovascular, neurological, inflammatory and related diseases and oncology. This manuscript is dedicated to 2011 Elsevier Masson SAS. All rights reserved. Prof. Goverdhan Mehta, Indian Institute of Science, Bangalore. Keywords: Natural products Clinical development Drug discovery Approved drugs 1. Intro