lncRNAs进化的保守性：序列,结构,功能.pdfVIP

Biochimica et Biophysica Acta 1840 (2014) 1063–1071 Contents lists available at ScienceDirect Biochimica et Biophysica Acta journa l homepage: /locate/bbagen Review Evolutionary conservation of long non-coding RNAs; sequence, structure, function Per Johnsson a, Leonard Lipovich b,c, Dan Grandér a, Kevin V. Morris d,e,⁎ a Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden b Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA c Department of Neurology, Wayne State University School of Medicine, Detriot, MI, USA d School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia e Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA a r t i c l e i n f o a b s t r a c t Article history: Background: Recent advances in genomewide studies have revealed the abundance of long non-coding RNAs Received 6 June 2013 (lncRNAs) in mammalian transcriptomes. The ENCODE Consortium has elucidated the prevalence of human Received in revised form 15 October 2013 lncRNA genes, which are as numerous as protein-coding genes. Surprisingly, many lncRNAs do not show the Accepted 21 October 2013 same pattern of high interspecies conservation as protein-coding genes. The absence of functional studies Available online 27 October 2013 and the frequent lack of sequence conservation therefore make functional interpretation of these newly dis-