复合型小细胞肺癌研究进展.PDFVIP

Med J Chin PLA, Vol. 43, No. 9, September 1, 2018 　799 ·综　　述· 复合型小细胞肺癌研究进展 李涛，张娟，胡毅 [摘要]　随着对小细胞肺癌认识和研究的不断深入，人们逐渐发现和揭示了一种病理类型为小细胞肺癌混合非小 细胞肺癌成分的疾病，即复合型小细胞肺癌(C-SCLC) 。与单纯型小细胞肺癌相比，C-SCLC无论在发生机制与起源、 临床生物学特性，还是在治疗和疾病预后等诸多方面都与之既有联系又有区别。基础研究的不断深入促进了C-SCLC 来源、机制、起病等多方面的研究进展。随着医疗技术和诊疗手段的发展，临床上对于C-SCLC 的发现和诊断率不断 提高，治疗上也取得了一定效果。本文对目前C-SCLC 的研究进展、诊断与分期、治疗现状和预后等进行归纳，以为 今后进一步的基础科研探索和临床治疗提供经验。 [关键词]　小细胞肺癌，复合型；治疗，预后 [中图分类号]　R734.2　　　　[文献标志码]　A　　　　[文章编号]　0577-7402(2018)09-0799-07 [DOI]　10.11855/j.issn.0577-7402.2018.09.14 Research progress of complex small cell lung cancer 1,2 1 1* LI Tao , ZHANG Juan , HU Yi 1Department of Oncology, Army Key Laboratory of Oncology, Key Laboratory of Tumor Targeting Therapy and Antibody Drugs of Ministry of Education, Chinese PLA General Hospital, Beijing 100853, China 2Department of Graduate Administration, Chinese PLA General Hospital/Medical School of Chinese PLA, Beijing 100853, China * Corresponding author, E-mail: huyi0401@ This work was supported by the Grant from Health Care Project Foundation of PLA (14BJZ04) [Abstract]　With the deepening of understanding and research of small cell lung cancer, a type of small cell lung cancer mixed with the pathological type of non-small cell lung cancer, namely complex small cell lung cancer (C-SCLC), has been discovered and revealed. Compared with pure small cell lung cancer, C-SCLC has its own connection and difference in many aspects such as its mechanism and origin, clinical biological characteristics, and the treatment and disease prognosis. With the continuous development of basic research, certain research results in many aspects have been achieved such as the origin, mechanism and onset of C-SCLC. With the developmen