轴突形态学改变在血管性痴呆发病机制中的作用.pdfVIP

7Abstract andsenile morethana to hasbeen to now,no plaque(SP)byyear．Up study reported axonal aftertransientfocalischemia． investigatechanges Inour observedthe ofaxonsofneuronsin study,we morphologicalchanges differentareasofischemic order hemispherefollowingischemia／reperfusion(I／R)in to the ofcerebralischemiaontheriskAD．Wealsoexaminedthe importance explore ofcerebralischemiaon amountandthe 13 the distributionofAandTau expression to anewresearchline the protein．Ourstudymayprovided studypathological ofAD． mechanism Method MaleWistar ratswere tomiddlecerebralocclusionfor30 subjected artery min； BDAwas intothedifferentbrain and injected areas(cortex，hippocampusstriatum)of mt InVivo used featureofthe by Tracingbymicrosyringemorphology pump．The axonshowed A13 Tau assessment；and wasexamined byBDA．was 42、phosphorylated andWestemBlotat 4w 6h，24h，1w，2w，3wand after byimmunohistochemistry MCAo． Results L Attheinitiationof axonsandvaricositiesinthe MCAO，swollen appeared ischemic andmotorcodexas tothe sensory compared corresponding conga—lateraland