课件：止血障碍血栓形成.ppt

Organization – Endothelial cell differentiation Resolution Organization - Rethrombosis Thrombus Clinical presentation: Arterial – coronary, carotid and femoral Acute MI, Angina CVA, TIA Claudication Venous – superficial veins, deep veins Thrombophlebitis, swollen, painful extremity Pulmonary embolus 后面内容直接删除就行 资料可以编辑修改使用 资料可以编辑修改使用 主要经营：网络软件设计、图文设计制作、发布广告等 公司秉着以优质的服务对待每一位客户，做到让客户满意！ 致力于数据挖掘，合同简历、论文写作、PPT设计、计划书、策划案、学习课件、各类模板等方方面面，打造全网一站式需求 * * * * Disorders of Hemostasis: Thrombosis John Lazarchick, M.D. Director, Hematopathology/Hemostasis August 30, 2001 Hypercoagulability Definition: Alteration in the hemostatic balance between blood fluidity and clot formation. This is due to genetic and acquired disorders which shift this balance toward excessive or inappropriate platelet aggregation and fibrin formation and predispose to thrombosis. Prethrombotic States 10 - inherited abnormalities resulting from mutations affecting the function of coagulant proteins and natural inhibitors 20 - acquired defects that either affect the endothelium, fluid flow or blood components. These defects are often superimposed on 10 defects Hypercoagulability:Prethrombotic States Virchow (1856) Abnormalities of blood vessels Abnormalities of fluid flow Abnormalities of blood components Blood Vessel Abnormalities Endothelial cell antithrombotic properties- PGI2, NO2, TFPI, PAI-1, heparans, thrombomodulin Genetic predisposition and acquired defects in these functions increase the risk of arterial and venous thrombosis Role of dietary excesses, hypertension, diabetes mellitus, obesity, smoking, lipid abnormalities in atherosclerosis Atherosclerosis Endothelial injury and dysfunction LDL cholesterol – oxidized LDL--- foam cells Diabetes mellitus – glycated LDL cholesterol Smoking – free radical production Hypertension – smooth muscle proliferation Genetic alterations – MTHFR mutations R. Ross. Atherosclerosis. NEJM 340:115-126, 1999 Atherosclerosis Site specific: Bifurcations Branc