D二聚体和肿瘤标志物与结直肠癌的相关性分析.docxVIP

D二聚体和肿瘤标志物与结直肠癌的相关性分析 赣州市人民医院 江西 赣州341000 作者简介：唐金凤，女，1979年，木科学历，研究方向：临床检验方面 通讯作者：肖久长，男，1970年，木科学历，副主任技师，从事医学检验工作 [摘要]目的：探究D二聚体和肿瘤标志物与结直肠癌的相关性。方法：随机从木 院2015年1月至2016年4月间收治入院的结直肠癌患者30例作为本次研究的 观察组，并选取同期在院体检的健康者30例作为对照组，分别检测两组硏究对 象静脉血中的D?二聚体和血清肿瘤标记物(主要检测CEA、CA199. CA724水平) 并予以观察组患者治疗，然后比较治疗前后上述指标变化情况，综合分析D二 聚体和肿瘤标志物与结直肠癌的相关性。结果：观察组血清CEA、CA199、CA724 以及D?二聚体水平显著高于对照组，R比较差异具有显著性(PV0.05),并且观 察组患者经过治疗后，CEA、CA199、CA724以及D■二聚体水平明显下降，且较 治疗前差异显箸(P0.05), 1血清CEA、CA199 CA724以及D?二聚体高水平 表达是影响结直肠癌临床预后的相关性因素。结论：血浆D二聚体和肿瘤标志 物表达与结直肠癌发牛情况有一定相关性，可以作为木病临床诊断及预后判断的 指标。 关键词：结直肠癌；D■二聚体；肿瘤标志物；相关性分析 【中图分类号】R446.1【文献标识码】A【文章编号】1001-5213(2016)08-0287-02 [abstract] objective: to explore the D dimer and the correlation between tumor markers and colorectal cancer. Methods: random from our hospital between January 2015 and April 2016colorectal cancer patients admitted between 30 cases as the study group, and the same period in hospital medical exami nations 30 cases of healthy subjects as control group, both groups was detected in the D ? dimer in venous blood and serum tumor markers (mainly detect CEA, CA199, CA724 levels) and observation group of patients, and then compare the index changes before and after the treatment, comprehensive analysis of D dimer and the correlation between tumor markers and colorectal cancer. Results: the observation group of serum CEA, CA199, CA724 and D - dimer level is significantly higher than the control group, and compared with significant differenee (P lt; 0.05), and the observation group of patients after treatment, CEA, CA199, CA724 and D ? dimer level declined obviously, and the sign讦icant differenee before treatment (P lt; 0.05), and serum CEA, CA199, CA724 and D - dimer express high levels of correlation factors of clinical prognosis of colorectal cancer. Conclusion: the serum D dimer and tumor markers in what is happe ning with colorectal can cer have certai n re leva nee, can be used as in dex of clin ical diag nosis and prog no sis judgeme nt. Key words: colo