eIF4E及其在妇科恶性肿瘤中的研究进展.docxVIP

eIF4E及其在妇科恶性肿瘤中的研究进 展 郑楠谭文华 哈尔滨医科大学附属第二临床医学院 摘要： 宫颈癌、子宫内膜癌和卵巢癌是女性生殖系统常见的三大恶性肿瘤，严重威胁着 女性的健康。随着社会发展，生活节奏加快，恶性肿瘤发病率逐年增加。真核细 胞起始因子 4E (eukaryotic initiation factor 4E, eIF4E)是与恶性肿瘤的 发牛发展密切相关的因子，其与mRNA的夕端帽子结构特异性结合，在转录起 始、翻译、细胞核内niRNA生成和细胞增殖中起重要作用，eTF4E活性受自身磷 酸化、翻译抑制蛋白的磷酸化等因素调节。研究发现eIF4E在妇科恶性肿瘤中高 表达，故可作为妇科肿瘤生物治疗的新靶点，协助疾病的诊断、早期预防和治 疗。 关键词: 真核细胞起始因子4E;生殖器肿瘤，女(雌)性;基因表达调控;肿瘤治疗方 收稿日期：2017-07-20 eIF4E and Its Progress in Gynecologic Malignancies ZHENG Nan TAN Wen—hua The Second Aff订iated Clinical Medical College of Harbin Medical University; Abstract： The three common malignant tumors of female reproductive system are cervical cancer, endometrial cancer, ovarian cancer, which are threatening the hea1th of women. With continuous economical development of soci ety, the pace of life is accelerating and the inci denee rate of malignemt diseases is incrcasing year by year. Eukaryotic initiation factor 4E (eIF4E) is one of the factors closely related to the occurrence and development of malignant tumors. It may specifically bind to the cap structure of mRNA 5’ end and play an important role in the initiation of transcription, translation and mRNA production in cel 1 nucleolus and cell proliferation. eIF4E activity regulated by factors such as the phosphorylation, the phosphorylation of translation inhibitory protein. The study founds that eIF4E is highly expressed in gynecologic malignancies can be expected as a new targeted biotherapy of gynecological mal igneint tumors, which assists in the diagnosis, early prevention and treatment of diseases. Keyword： Eukaryotic initiation fnctor-4E; Genital neoplasms, female; Gene expression regulation; Ant ineoplastic protocols; Received： 2017-07-20 真核生物蛋白的合成有着相同的系统，在这一体系屮存在某些调节因子，仅在 某些病理条件下差异表达，从而在翻译水平影响蛋口质的合成，产生质的变化, 诱发机体出现病理变化。儿乎所有真核转录信使都有一个5’ ni7Gppp N帽子结构 和由50~300个核昔酸组成的3 ploy A尾,这是帽依赖性翻译最常见的蛋白质 合成机制。真核细胞起始因子 4E （eukaryotic initiation factor 4E, e TF4E） 是mRNA帽结合鳞蛋白，是帽依赖性in RNA翻译过程中的限速因子。近年实验研 究发现，c IF4E在很多恶性肿瘤组织中表达增高，c IF4E倾向翻译具有复杂和 高度结构化