急进与久居高原者血糖血脂和电解质变化对复方甲基异恶唑片药动学.PDF

急进与久居高原者血糖、血脂和电解质变化对复方甲基异噁唑片药动 学影响 高芬，冯喜英，杜发茂(青海大学附属医院呼吸科，西宁 810001) 摘要：目的 研究急进与久居高原者血糖、血脂和电解质含量变化对复方甲基异噁唑片药动学影响。方法 采用高效液 相色谱法测定平原、急进高原和久居高原3 组2 个群体健康汉族男性青年志愿者口服单剂量复方甲基异噁唑片前后 15 个 时间点血浆药物浓度。应用全自动生化仪测定3 组血糖、血脂和电解质含量。采用DAS 2.0 和SPSS 13.0 统计软件计算3 组受试者口服复方甲基异噁唑片后磺胺甲噁唑的药动学和血糖、血脂和电解质参数。结果 急进高原组和久居高原组受 试者的药动学参数Ke 、MRT 、t1/2、Cl 与平原组相比有显著性差异，急进高原组t1/2、V 与久居高原组相比有显著性差异。 久居高原组血糖和血脂含量高于平原组和急进高原组，载脂蛋白含量A 则显著减少(P 均0.01) 。急进高原组K 含量增加， 与平原组相比有统计学意义(P0.05) 。久居高原组Cl 和 Ca 与急进高原组相比差异显著(P 分别0.05 和 0.01) ，急进高原 组与久居高原组P 均低于平原组(P0.01) 。葡萄糖(GLU)和胆固醇(TCH)与t1/2 正相关，APOA 与t1/2 和V/F 负相关(P0.01) 。 K 和Ca 与AUC 正相关(P 分别小于0.05 和0.01) ，与Cl/F 和V/F 负相关(P 分别小于0.05 和0.01) 。Cl 与V/F 负相关(P0.05) 。 结论 急进与久居高原者血糖、血脂和电解质含量变化对复方甲基异噁唑片药动学有显著影响。 关键词：高原低氧；药动学；复方甲基异噁唑片；血糖；血脂；电解质 中图分类号：R969.1 文献标志码：A 文章编号：1007-7693(2010)03-0239-04 Effects of Blood Glucose, Lipid and Dielectric on SMZCo Pharmacokinetics After Short- and Long-time Exposure to High-altitude GAO Fen, FENG Xiying, DU Famao(Respirative Department, Qinghai University Hospital, Xining 810001, China) ABSTRACT: OBJECTIVE To study the effects of blood glucose, lipid and dielectric on SMZCo pharmacokinetics after short- and long-time exposure to high altitude. METHODS The young volunteers of healthy male Chinese Hans were divided into three groups: the plain group, the rapid ascent group and the adaptation group. All subjects in this study were treated with a single dose of SMZCo tablets, and their plasma concentration of SMZ were determined by HPLC and the blood glucose, lipid and dielectric were determined by automatic biochemistry instrument. Datas obtained were analyzed by DAS 2.0 and SPSS 13.0 software. RESULTS There were significant differences in pharmacokinetics parameters of Ke, MRT, t1/2 and Cl comparing the rapid ascent group and the adaptation group wi