课件：危重感染抗菌药应用.ppt

主要经营：课件设计，文档制作，网络软件设计、图文设计制作、发布广告等 秉着以优质的服务对待每一位客户，做到让客户满意！ 致力于数据挖掘，合同简历、论文写作、PPT设计、计划书、策划案、学习课件、各类模板等方方面面，打造全网一站式需求 除了抗感染的药物选择河使用时间的恰当问题以外，这几年我重点在考虑，如何优化抗感染药物治疗方案，包括给药剂量、给药频率和给药持续时间。 Inadequate treatment of hospital-acquired pneumonia, particularly in the ICU setting, is increasingly being recognized as a potential cause of patient mortality and morbidity. Adequate therapy may be defined as use of an antibiotic(s) effective against an identified pathogen(s) at the time of its identification and takes into consideration proper dosing, proper interval administration, penetration to the infective site, proper route and combination therapy. ATS/IDSA Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388–416. One hundred forty-seven patients (29.9%) received inadequate antimicrobial treatment for their bloodstream infections. The hospital mortality rate of patients with a bloodstream infection receiving inadequate antimicrobial treatment (61.9%) was statistically greater than the hospital mortality rate of patients with a bloodstream infection who received adequate antimicrobial treatment (28.4%; relative risk, 2. 18; 95% confidence interval [CI], 1.77 to 2.69; p 0.001).? A prospective multicenter study of 1 years duration. Medical and surgical ICUs in 30 hospitals all over Spain. Of a total of 16,872 patients initially enrolled into the study, 530 patients developed 565 episodes of pneumonia after admission to the ICU. Empiric antibiotics were administered in 490 (86.7%) of the 565 episodes of pneumonia. The antimicrobials most frequently used were amikacin in 120 cases, tobramycin in 110, ceftazidime in 96, and cefotaxime in 96. Monotherapy was indicated in 135 (27.6%) of the 490 episodes, a combination of two antibiotics in 306 episodes (62.4%), and a combination of three antibiotics in 49 episodes (10%).?Attributable mortality was 16.2% in patie