应用频域OCT观察高度近视黄斑裂孔脉络膜厚度的研究.docxVIP

应用频域OCT观察高度近视黄斑裂孔脉络膜厚度的研究 北京军区总医院北京市100700 摘要：目的：通过频域OCT分析高度近视黄斑裂孔(HM-MH)患者的黄斑部脉 络膜厚度并探讨其相关影响因素。方法：纳入26例2012年3月至2014年10 月于北京安贞医院确诊为单眼HM-MH的患者。通过频域光学相干断层扫描 (SD-OCT),分别对黄斑中心凹下及其鼻侧、撷侧、上方、下方各1.5mm处的脉 络膜厚度进行测量。屈光度、眼轴长度、黄斑中心凹下及不同位点的脉络膜厚度 差异比较采用配对t检验。Logistic回归分析年龄、屈光度、眼轴长度、不同位点 的脉络膜厚度与HM-MH的关系。结果：HM-MH患眼与对侧眼相比，眼轴长度 与等效球镜度数的差异无统计学意义。眼的黄斑中心凹下脉络膜最薄 (132.33 plusmn; 32.56micro;m),与对侧眼相比(149.11 plusmn; 28.36micro;m),差异有统计学意义(P二0.010)。Logistic ln|归分析显示，黄斑中 心凹下脉络膜变薄是HM-MH的危险因素(OR, 1.95； 95%CI, 1.52-2.76； p = 0.016) 结论：黄斑中心凹下脉络膜变薄可能是HM-MH发牛的危险因素。 关键词：高度近视；黄斑裂孔；脉络膜厚度 [Abstract]Objective： To exami ne choroidal thick ness and its relati on ship with axial len gth and spherical equivalent by spectral domain optical cohere nee tomography (SD-OCT) in patients with high myopic macular hole (HM-MH)?Methods： We prospectively recruited 26 cases of HM-MH in Beijing Anzhen Hospital from March 2012 to October 2014.SD-OCT was used to measure choroidal thickness subfoveally and at 1.5mm superiorly, inferiorly, nasally and temporally.Paired t test was con ducted to assess the difference of spherical equivalent, axial le ngth and choroidal thickness between HM-MH group and controls.Logistic regression analysis was performed to evaluate the correlation between age, spherical equivalent, axial length, choroidal thickness and HM-MH.Results： The differe nee of spherical equivale nt and axial length between HM?MH group and controls was not significant (P 0.05) .Subfoveal choroidal thickness was decreased in HM-MH group compared with controls (132.33 plusmn; 32.56micro;m vs.149.11 plusmn; 28.36micro;m) .The difference was significa nt(P=0.010 ).L ogistic regression dem on strated that decreased choroidal thickness at subfoveal location was associated with HM-MH (OR, 1.95； 95%Cb 1.52-2.76； p = 0.016) .Conclusions： Decreased subfoveal choroidal thickness may be one of the risk factors for development of HM-MH. ［Key words］High myopia； Mcular hole； Choroidal thickness 作为病理性近视的并发症之一，高度近视继发的黄斑裂孔(High myopic