银杏叶胶囊联合阿司匹林及胞二磷胆碱治疗急性脑梗死的疗效研究资料.docVIP

银杏叶胶囊联合阿司匹林及胞二磷胆碱治疗急性脑梗死的疗效研究 第 PAGE \* Arabic \* MERGEFORMAT 12 页 上海市科委基金资助项目（11DZ1921206）通讯作者：姚晨玲，E-mail：yao.chenling@zs-hospital.sh.cn 上海市科委基金资助项目（11DZ1921206） 通讯作者：姚晨玲，E-mail：yao.chenling@zs-hospital.sh.cn 摘要 目的：观察银杏叶胶囊联合阿司匹林及胞二磷胆碱治疗急性脑梗死前后的神经功能缺损评分（MESS评分）、日常生活能力评定（Barthel指数）及血清超敏C反应蛋白（hs-CRP）、超氧化物歧化酶（SOD）、丙二醛（MDA）、内皮素-1（ET-1）、血栓素（TXB2）水平的变化，探讨银杏叶提取物清除氧自由基、扩张脑血管等作用及疗效。 方法：将44例急性脑梗死患者随机分为两组，对照组采用阿司匹林及胞二磷胆碱等常规药物进行脑卒中治疗，试验组在用药组基础上加用银杏叶胶囊口服治疗，观察两组患者治疗14d前后的神经功能缺损评分、日常生活能力改善情况、临床总疗效及治疗7d前后血清hs-CRP、SOD、MDA、ET-1、TXB2水平的变化。 结果：试验组与对照组治疗前后的MESS评分、Barthel指数、血清hs-CRP水平相比，其差异无统计学意义（p0.05），但临床总疗效、血清SOD、MDA、ET-1、TXB2水平较对照组改善明显（p0.05）。 结论：银杏叶胶囊联合阿司匹林及胞二磷胆碱治疗急性脑梗死疗效明显，并可升高血清SOD水平，降低MDA、ET-1、TXB2水平，且无不良反应，具有一定的临床应用价值。 关键词：银杏叶；急性脑梗死；神经功能缺损评分；hs-CRP；SOD；MDA；ET-1；TXB2 Abstract： Background：To observe the MESS score,Barthel Index,hs-CRP,SOD,MDA,ET-1,TXB2 levels during the treatment in acute cerebral infarction using of Gingko Biloba Extract combined with Aspirin and Cytidine Diphosphate Choline,and discuss the mechanism of GBE in the treatment of acute cerebral infarction. Methods：Patients diagnosed as acute cerebral infarction were randomly divided into two groups. Control group took Bayaspirin,cytidine diphosphate choline and other convetional treatments,while the test group received Gingko Biloba Extract capsules combined with the medicine which used in the control group. The parameters measured during the study were MESS score, Barthel Index,outcomes, and hs-CRP,SOD,MDA,ET-1,TXB2 levels. Results：Contrast with the control group,the MESS score,Barthel Index and hs-CRP levels of 7th day and 14th day in test group is not improved(p0.05),but the total clinical effects and the SOD,MDA,ET-1,TXB2 levels are obviously improved(p0.05). Conclusion：Via increasing the SOD levels and decreasing the MDA,ET-1,TXB2 levels,the treatment of Gingko Biloba Extract combined with Aspirin and Cytidine Diphosphate Choline in acute cerebral infarction is effective and safe. Key words:Gingko Biloba E