多指标综合评分法优选抗感胶囊提取工艺-中国中医药信息杂志.PDF

2019 年3月第 26卷第3期 中国中医药信息杂志 ·77· 多指标综合评分法优选抗感胶囊提取工艺 1 2 1，2 1 朱广平 ，戴雨晨 ，刘顺 ，倪文澎 1.南京中医药大学附属医院，江苏 南京 210029 ；2.南京中医药大学，江苏 南京 210023 摘要：目的 优化抗感胶囊提取工艺。方法 采用单因素考察结合正交试验设计法，以方中金银花和连翘 的有效成分绿原酸、木犀草苷、连翘酯苷 A 的含量和浸膏得率为综合评分指标，考察溶剂用量、提取时间、 提取次数 3 个因素对抗感胶囊水提工艺的影响，并进行验证试验。结果 最优提取工艺为：加 12 倍量水，回 流提取 2 次，每次提取 1.5 h。结论 本研究优选的提取工艺简单、稳定可行，对抗感胶囊的生产工艺制定具 有一定的指导意义。 关键词：抗感胶囊；绿原酸；木犀草苷；连翘酯苷 A ；综合评分法；提取工艺 中图分类号：R283.5 文献标识码：A 文章编号：1005-5304(2019)03-0077-05 DOI：10.3969/j.issn.1005-5304.2019.03.017 开放科学（资源服务）标识码（OSID）： Optimization of Extraction Technology of Kanggan Capsules by Multi-index Comprehensive Evaluation Method 1 2 1,2 1 ZHU Guangping , DAI Yuchen , LIU Shun , NI Wenpeng 1. Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China; 2. Nanjing University of Chinese Medicine, Nanjing 210023, China Abstract: Objective To optimize the extraction technology of Kanggan Capsules. Methods Single factor test combined with orthogonal test design was used, and the contents of chlorogenic acid, cynaroside and forsythoside A in Lonicerae Japonicae Flos and Forsythiae Fructus in Kanggan Capsules and extract yields were taken as comprehensive evaluation indexes to examine the effects of solvent dosage, extraction time and extraction times on the extraction technology of Kanggan Capsules. Validation test was conducted. Results The optimal extraction technology was as follows: 12 times of water extracted twice under reflux for 1.5 h each time. Conclusion