广州市普通人群非酒精性脂肪性肝病的自然病程及危险因素-@@专业论文.docxVIP

英文摘 英文摘要 PAGE PAGE 5 and 59(67.0%) improved at the end-point in the non-MS group(P=0.024). The two groups significant differences, show that MS significantly worsened the natural course of NAFLD. Ordinal Logistic regression fined that HDL-C(OR:2.052，95%CI: 1.137-4.000；P=0.017) and PFG(OR:2.040，95%CI: 1.163-4.000；P=0.013) worsened the natural course of NAFLD in the five components of MS. The overall prevalence of cardiovascular disease(CVD) in all the patients was 63.0%. In the NDFLD subgroup ,69.4% had cardiovascular disease compared to 58.7% in the subgroup without NAFLD(P=0.005). Single factor analysis: NAFLD group compared with controls found: physical activity, body mass index(BMI), diastolic blood pressure(DBP), triglyceride(TG), high-density lipoprotein(HDL-C), uric acid(UA), fasting plasma glucose(FBG) was significant difference(P＜0.05). Binary-Logistic regression analysis showed the independent risk factors for NAFLD were BMI(OR：5.340，95%CI：3.596-7.928；P=0.000), DBP(OR： 1.706，95%CI:1.204-2.418；P=0.003), TG(OR: 3.017，95%CI：2.241-4.060；P=0.000), UA(OR: 1.569，95%CI：1.168-2.108；P=0.003), FPG(OR：1.979，95%CI：1.292-3.032； P=0.002).And age(OR: 0.547，95%CI: 0.401-0.745；P=0.000) was protective factor against NAFLD development. Conclusions NAFLD is a benign diseases and the incidence of cirrhosis is low, the prevalence and incidence of which in the general population of Guangzhou is higher. Some components of MS are the risk factors of NAFLD, which also aggravate its natural course. The prevalence of CVD for NAFLD is significantly higher than the general population, The dangers of non-alcoholic fatty liver disease not only confined to the liver itself, but also related to cardiovascular disease and other diseases caused by MS. Therefore, underestimated its dangers if only concerned with NAFLD develop to cirrhosis and liver cancer. Key word ： non-alcoholic fatty live disease; incidence; prevalence; natural course; Metabolic Sy