复方栀子注射液解热抗炎作用的研究-中国中医药信息杂志.PDF

2005年 5月第 12卷第 5期 中国中医药信息杂志 ·25· 复方栀子注射液解热抗炎作用的研究 1 1 1 2 杨 鸿 ,李 慧 ,张文生 ,指导：王永炎 (1.北京师范大学资源药物与中药资源研究所,北京 100088；2.中国中医研究院,北京 100700) 摘要：目的 研究复方栀子注射液解热抗炎的作用。方法 通过家兔细菌内毒素发热、大鼠干酵母发热实 验观察其解热作用；通过大鼠角叉菜胶所致足肿胀、小鼠二甲苯耳肿胀模型观察其抗炎作用。结果 复方栀子注 射液 2 mL/kg 剂量组能明显减轻细菌内毒素所致家兔发热反应和干酵母所致大鼠发热反应；2、4 mL/kg 剂量组能 显著抑制角叉菜胶所致大鼠足肿胀和二甲苯所致小鼠耳廓肿胀。结论 复方栀子注射液具有明显的解热、抗炎作 用。 关键词：复方栀子注射液；解热；抗炎 中图分类号：R285.5 文献标识码：A 文章编号：1005-5304(2005)05-0025-03 Effects of Compound Zhizi Injection on Antipyretic and Anti-inflammatory Function YANG Hong, LI Hui, ZHANG Wen-sheng, et al (Institute of Natural Medicine Chinese Medicine Resources, Beijing Normal University, Beijing 100088,China) Abstract ：Objective To study the influence of compound Zhizi injection on antipyretic and anti-inflammatory function. Method Prove the antipyretic function of compound Zhizi injection in bacterial endotoxin-induced fever rabbits and yeast-induced febrile rats, anti-inflammatory action in cross vegetable glue-induced acute inflammation in rats and in dimethy benzene-induced auricular inflammatory edema in mice. Result Compound Zhizi injection 2 mL/kg had a remarkable antipyretic function in rabbit and rat fever model. 2, 4 mL/kg dose group had a obvious inhibitory function in acute inflammatory rats and mice (P 0.05, P 0.01). Conclusion Compound Zhizi injection has a remarkable antipyretic and anti-inflammatory function. Key words：compound Zhizi injection；antipyretic function；anti-inflammation 复方栀子注射液是根据王永炎院士多年临床经验方,采 二甲苯,北京益利精细化学品有限公司产品,批号 用现代制剂工艺,提取栀子、灯盏花等中药的有效组分制备而 热原测定仪,型号 WRY-2000,上海达亿实业有限公