达英35联合二甲双胍治疗36例多囊卵巢综合征临床疗效分析.docxVIP

达英?35联合二甲双肌治疗36例多囊卵巢综合征临床疗效分 析 裴阳琴1张春花2 (1江苏省常州市丽华医院妇科 江苏 常州213000) (2淮安市妇幼保健院妇科江苏淮安223000) 【摘要】目的：观察达英?35联合二甲双弧治疗多囊卵巢综合征(PCOS)的临 床疗效。方法：36例临床病人用达英?35联合二甲双弧治疗三周期，观察治疗前 后患者的临床症状，治疗性激素的水平，瘦素(LP)和膜岛素抵抗指数(HOMA-IR), 性激素结合球蛋白(SHBG),身体质量指数(BMI)和卵巢形态学指标，比较生 殖内分泌指标糖代谢指标的变化。结果：FSH/LH比值，雄激素水平，瘦素和胰 岛素抵抗指数均低于治疗前，和性激素结合球蛋口明显高于治疗前(PV0.01)。 体重下降(P0.05)治疗后，卵巢体积明显低于治疗前(PV0.05)。结论：达英 -35联合二甲双弧可有效改善多囊卵巢综合征患者的胰岛素抵抗状态，降低血中 雄激素水平并恢复生育功能，治疗多囊卵巢综合征安全有效。 【关键词】 达英?35；二甲双弧；多囊卵巢综合征 【中图分类号】R711.75 【文献标识码】A 【文章编号】2095-1752 (2016) 08-0189-02 Clinical analysis of Diane -35 Combined with Metformin in thetreatment of 36 cases with polycystic ovary syndrome l.PeiYa ngqin ,2.YangChu nhua 丄 Changzhou Lihua hospital gyn ecology Cha ngzhou, Jiangsu213000;2.Huaian City, MCH Gynecology Huaian in Jiangsu223000 .China [Abstract lObjective To investigate the clinical effect of Diane -35 combined with metforminin in the treatment of polycystic ovary syndrome (PCOS) Method 36 cases of clinical patients Eat Diane-35 and metformin total of three cycles.Analysis of treatment before and after clinical symptoms,Lp,HOMA-IR,Sex Hormones,SHBG,BMIO,varian morphology and other indicators.Comparison of reproductive en docri no logy and sugar metabolism in both indicators cha nge. Result An droge n levels, LH / FSH ratio, insuli n resista nee and lepti n in dices after treatme nt are lower than before the treatment,SHBG were significantly higher than before treatment(Plt;0.01).BMI decreased after treatment(Plt;0.05).Ovarian volume than before treatment significantly reduced(Plt;0.05). Conclusion Diane-35 combined with metformin use treatments Polycystic Ovary Syndrome is safe and effective. May improve in suli n resista nee in patie nts.Reduces PCOS and restore reproductive function. 【Key words］ Diane-35;Metformin;PCOS 多囊卵巢综合征(PCOS)是一种由生殖内分泌和代谢功能紊乱引起的常见 的内分泌疾病。它是一种常见的遗传异质性［1］,它的发病率是5%至10%的育龄 妇女，原因仍然是未知的。我院2012年1月?2014年12月采用达英?35联合二 甲双肌治疗PCOS患者36例，获得效果满意，现报道如下： ?资料与方法 1.1 一般资料 选择在我院就诊的36例PCOS患者。年龄20?34岁，平均(25.3plusmn;5.12)