AMPK参与肿瘤能量代谢研究进展-海南医学.PDFVIP

Hainan Med J, Jan. 2017, Vol. 28, No. 1 doi:10.3969/j.issn.1003-6350.2017.01.035 ·综 述· AMPK 参与肿瘤能量代谢研究进展 1 1 2 1 张小燕 ，李志艳 ，唐海林 ，傅念 (1. 南华大学附属南华医院消化内科，湖南 衡阳 421002 ； 2. 中山大学肿瘤防治中心乳腺科，广东 广州 510060) 【摘要】 肿瘤细胞具有独特的能量代谢方式—Warburg 现象，而肿瘤的发生发展、转移与能量代谢密切相 关。腺苷酸活化的蛋白激酶(AMPK)是细胞中重要的能量感受器，主要参与维持代谢应激下能量平衡和氧化还原 稳态，与肿瘤能量代谢异常密切相关。活化的AMPK 可以增强分解代谢、抑制合成代谢、上调ATP 水平，也参与调 节糖代谢、胆固醇代谢、脂肪酸及蛋白质代谢等过程，为细胞的生长过程提供能量储备，应对能量不足；同时活化的 AMPK 还与肿瘤新生血管形成、转移、炎症等病理过程息息相关。本文主要对AMPK 的结构、活化机制、参与物质 能量代谢以及与肿瘤形成的关联做一综述。 【关键词】AMPK ；能量代谢；肿瘤形成 【中图分类号】R730 【文献标识码】A 【文章编号】 1003—6350（2017 ）01—0111—05 Research progress of AMPK participation in tumor cell energy metabolism. ZHANG Xiao-yan 1, LI Zhi-yan 1, TANG Hai-lin 2, FU Nian 1. 1. Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang 421002, Hunan, CHINA; 2. Department of Galactophore, Sun Yat-Sen University Cancer Center, Guangzhou 510000, Guangdong, CHINA 【Abstract 】 Tumor cells have a unique energy metabolism way—Warburg Phenomenon. The occurrence and de- velopment of tumor is closely related to energy metabolism. AMP-activated protein kinase (AMPK) is essential cellular energy sensor, and mainly participates in maintaining the energy balance and redox homeostasis under metabolic stress. It is closely related to the abnormal energy metabolism. Activated AMPK could enhance catabolism, inhibite the synthe- sis, increase ATP levels, and is also involved in the regulation of glycometabolism, cholesterol metabolism, fatty ac