综述T型钙通道阻滞剂的临床应用进展.PDF

·1068 · 现代药物与临床 Drugs Clinic 第 29 卷 第 9 期 2014 年 9 月 • 综 述 • T 型钙通道阻滞剂的临床应用进展 * 高 柳，郭 颖，贾友宏 ，李一石 中国医学科学院 北京协和医学院 阜外心血管病医院 卫生部心血管药物临床研究重点实验室，北京 100037 摘 要：T 型钙通道是一种低电压钙通道，在体内分布广泛，参与多种生理过程。T 型钙通道阻滞剂是目前关注较多的一种 新型钙通道阻滞剂，除具备与传统钙通道阻滞剂相似的降压作用外，还具有如降低心肌自律性、抗心肌重塑、保护肾功能、 抗交感神经等药理作用。对 T 型钙通道阻滞剂的药理作用、药物相互作用与不良反应等研究进展进行综述，从而了解 T 型 钙通道阻滞剂在临床实践中的应用现状，探索和开发其在临床实践中的新使用价值。 关键词：T 型钙通道阻滞剂；临床应用；不良反应 中图分类号：R972 文献标志码：A 文章编号：1674 - 5515(2014)09 - 1068 - 05 DOI: 10.7501/j.issn.1674-5515.2014.09.026 Research progress on clinical application of T-type calcium channel blockers GAO Liu, GUO Ying, JIA You-hong, LI Yi-shi Key Laboratory of Clinical Trial Research in Cardiovascular Drugs Ministry of Health, Cardiovascular Institute and Fuwai Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing 100037, China Abstract: T-type calcium channel is a kind of low voltage calcium channel, widely distributed throughout the body and participates in many physiological activities. Now increasing attention has been focused on the blockers of the T-type calcium channel. It has not only the function of lowing blood pressure like traditional calcium channel blockers, but also some pharmacological activities such as inhibiting cardiac muscle autorhythmicity, anti-cardiovascular remodeling, renal protective action, and resistance to the sympathetic nervous. This paper summarizes the pharmacological activities, drug interaction, and side effects of T-type calcium channel blockers, which helps to understand the application status of the T type calcium channel blockers in clinical practice, and explore and develop new use value of T-type calcium channel blockers. Key words: T-type calcium channel blockers; clinical application; side effects 钙通道