阿德福韦酯Ⅰ晶型非等温热分解动力学-天津科技大学学报.PDF

第 30 卷 第 1 期 天津科技大学学报 Vol. 30 No. 1 2015 年 2 月 Journal of Tianjin University of Science Technology Feb. 2015 DOI:10.13364/j.issn.1672-6510 阿德福韦酯 Ⅰ晶型非等温热分解动力学 周先强，朱 亮，沙作良，王彦飞，杨立斌 (天津市海洋资源与化学重点实验室，天津科技大学海洋科学与工程学院，天津 300457) 摘 要 ：通过溶析结晶制备阿德福韦酯Ⅰ晶型．用差示扫描量热分析 (DSC) 粉末 X 射线衍射 (XRD)方法对Ⅰ晶型进 行表征 ，通过热重分析对Ⅰ晶型进行非等温热分解动力学研究 ，结果表明阿德福韦酯Ⅰ晶型在升温过程中会出现 3 个 热分解阶段．研究了 3 个阶段的热分解过程机理及其分解动力学，综合运用 FWO (Flynn-Wall-Ozawa)模型和迭代法分 析 3 个阶段的热分解动力学数据，获得了 3 个阶段的热分解动力学参数和方程． 关键词 ：阿德福韦酯；晶型；热分解；动力学 中图分类号：O736 文献标志码 ：A 文章编号 ：1672-6510 (2015)01-0046-05 Non-isotherm Pyrolysis Kinetics of Adefovir Dipivoxil Polymorph Ⅰ ZHOU Xianqiang ，ZHU Liang ，SHA Zuoliang ，WANG Yanfei ，YANG Libin (Tianjin Key Laboratory of Marine Resources and Chemistry ，College of Marine Science and Engineering ， Tianjin University of Science Technology ，Tianjin 300457 ，China) Abstract ：Adefovir dipivoxil polymorph Ⅰ was prepared with drowning-out approach and its crystal form was charactered by using differential scanning calorimetry and X-ray diffraction methods. Non-isothermal thermogravimetry method was used to study the pyrolysis process of adefovir dipivoxil. It was found that the pyrolysis process can be classified into three decomposition stages. The pyrolysis kinetic equation and parameters at each stage were obtained through analyzing the ex- perimental data using the FWO (Flynn-Wall-Ozawa)model and the iterative method ，r