星点试验设计优化甲维盐微囊悬浮剂制备工艺-吉林农业大学学报.PDF

吉林农业大学学报 2012，03 Journal of Jilin Agricultural University E-mail:jlndxb@ 星点实验设计优化甲维盐微囊悬浮剂制备工艺∗ 1,2 1 1 2 1 1,** 曲桂霞 ，刘 学 ，李晓凤 ，时 慧 ，王玉峰 ，李守君 1.佳木斯大学药学院，佳木斯 154007；2.佳木斯大学附属第一医院，佳木斯 154002 摘 要：以包封率为指标采用星点试验设计-效应面优化法对甲维盐微囊制备处方工艺进行优化。将微囊制备时的pH 、 温度、搅速作为考察因素，通过对微囊包封率测定结果进行二项式拟合绘制三维图像，从直观图中选取最佳试验设 计点。二项式线性拟合Radj=0.927 可用于对试验结果的预测，微囊制备pH 为 3.58 ，温度30.06 ℃，搅速选取700 r/min ， 包封率可达 96.71% 。结果表明，星点试验设计可对甲维盐微囊制备工艺进行优化，且优化效果良好。 关键词：星点实验设计；甲维盐；微囊；包封率 中图分类号：R944 文献标识码：A 文章编号：1000-5684(2012) /kcms/detail/22.1100.S1527.003.html 网络出版地址： Optimized Formulation of Emamectin Benzoate Microcapsule Using Central Composite Design 1,2 1 1 2 1 1 QU Gui-xia , LIU Xue , LI Xiao-feng , SHI Hui , WANG Yu-feng , LI Shou-jun 1. College of Pharmacy, Jiamusi University, Jiamusi 154007, China; 2. First Affiliated Hospital of Jiamusi University, Jiamusi 154002, China Abstract: Rotational central composite design was employed to optimize the microcapsule’s encapsulation efficiency of the emamectin benzoate. Independent variables of the experimental design were pH, temperature and stirring speed. The encapsulation efficiency of emamectin benzoate was fitted to a binomial liner fitting, through which three dimensional response surface graphs were produced. Experimental conditions were optimized from the stationary point of the response surfaces. The binomial liner equation Radj =0.927 can be used to predict experimental results of microcapsule preparation, pH 3.58, temperature 30.06 ℃ and speed 700r/min, and the encapsulation efficiency could reach 96.71%. Central composite design can optimize the