综述·石头花属植物的化学成分及药理作用研究进展-天津中草药杂志社.PDF

·280 · 中草药 Chinese Traditional and Herbal Drugs 第 46 卷 第 2 期 2015 年 1 月 ·综 述· 石头花属植物的化学成分及药理作用研究进展 解龙霄，孙得峰，汪海洋，姚庆强，孙敬勇* 山东省医学科学院药物研究所，济南大学 山东省医学科学院医学与生命科学学院，山东省罕少见病重点实验室，山东 济南 250062 摘 要：石头花属植物主要化学成分为黄酮类、环肽类、甾醇类、挥发油、三萜及其皂苷等化合物，具有抗肿瘤、抗肥胖、 抗糖尿病、保肝、抗氧化等药理作用。在检索国内外相关文献的基础上，对石头花属的植物资源、化学成分及药理作用进行 综述，以期为石头花属植物进一步研究和开发利用提供参考。 关键词：石头花属；植物资源；黄酮类；抗肿瘤；抗氧化 中图分类号：R282.71 文献标志码：A 文章编号：0253 - 2670(2015)02 - 0280 - 13 DOI: 10.7501/j.issn.0253-2670.2015.02.024 Research progress on chemical constituents in plants of Gypsophila L. and their pharmacological activities XIE Long-xiao, SUN De-feng, WANG Hai-yang, YAO Qing-qiang, SUN Jing-yong Key Laboratory of Rare and Uncommon Diseases of Shandong Province, Shandong Academy of Medical Sciences, School of Medicine and Life Sciences, University of Jinan, Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China Abstract: The plants in Gypsophila L. mainly contain chemical constituents, such as flavonoids, cyclic peptides, sterols, volatile oil, triterpenoid saponins, and other compounds which possess antitumor, anti-obesity, anti-diabetic activity, hepatoprotective activity, anti-oxidation, and so on. On the basis of the retrieval of relevant literature, this paper summarizes the progress on resources, chemical composition, pharmacological action, and clinical application of the plants in Gypsophila L., and provides the references for the further study and development of the plants in Gypsophila L. Key words: Gypsophila L.; plant resources; flavonoids; antitumor; anti-oxidation 石头花属 Gypsophila L. 为石竹目石竹科植物， 减。河北石头花、华山石头花、刺序石头花和细叶 约 150 种，分布于亚洲、欧洲及南美洲。我国有 18 石头花为我国特有种[4] 。目前研究发现长蕊石头花、 种 1 变种[1] 。石头花属植物可供药用，也可供观赏。 草原石头花、大叶石头花等可供药用。按多年生或 其具有清热凉血、活血化瘀、消肿止痛、化腐生肌 一年生、茎直立或斜升、植株高矮、