刘颖穴位注射治疗变应性鼻炎疗效和安全性Meta分析.doc

穴位注射治疗变应性鼻炎疗效和安全性的Meta分析 刘颖 胡浩刘敏彳张勤修（1?成都屮医药大学附属医院,四川 成都,6100722 刘颖 胡浩 刘敏彳张勤修 （1?成都屮医药大学附属医院, 四川 成都,610072 2.成都双流县中医院，四川 成都双流县，610200 3?都江堰市人民医院，四川 都江堰市611800） 摘要目的：评价穴位注射治疗变应性鼻炎的有效性。方法：按照国际Cochrane 协作网的系统评价方法，计算机检索Cochrane图书馆随机对照试验库（CCTR）、 Pubmed、屮国生物医学数据库（CBM）、清华期刊全文数据库（CNKI）、万方数 据库、维普数据库（截至2009年）中有关穴位注射药物治疗变应性鼻炎的随机 对照研究。采用Jadad法评价文献质量，用Rev. Man 4.2. 10对6篇RCT研究结 果进行合并，并检验其异质性，根据异质性结杲选择相应的效应模型，绘制漏斗 图，用Met。分析法评价穴位注射治疗变应性鼻炎的有效性和安全性。结果：共 检索到符合纳入标准的随机临床试验文献6篇，高质量文献1篇，Meta分析穴 位注射药物治疗变应性鼻炎与对照组相比较，大多数穴位注射的药物对变应性鼻 炎的临床症状冇较明显的改善作用，但不同药物，不同穴位，疗效有所差别。所 纳入文献方法学质量评价普遍较低。结论:本研究提示中西医结合穴位注射治疗 变应性鼻炎，可提高临床疗效。但由于纳入的临床试验方法学质量相对偏低，样 木量较少，各类药物及穴位研究之间存在异质性高，不同药物及不同穴位同一?指 标不宜再次合并分析等多种局限性，故对这个结果应持客观态度。 关键词：穴位注射变应性鼻炎随机对照试验系统评价 A Meta-analysis of Treatment on Allergic Rhinitis with Acupoint Injection [Abstract! Objective:To review systematically whether there are enough existing evidences that acupoint injection is effective in the treatment. Methods:Cochrane Controlled Trials Register (CCTR) (most recent issue) PubMed and China National Knowledge Infrastmcture (CNKI)、Chinese Biological Medicine database(CBM)、 WanFang data and WeiPu data were widely referred. The Chinese journals related to TCM during 2009 were searched by hand. Using Jadad method to value the qualities of these papers gained from these databases and then analysed and integrated the experiment resaults from 6 paper.Three authors independently assessed trial qualities and extracted data from these Randomized Controlled Trails, then input them into the Mete-analysis by Rev.Men 4.2.10.Results:6 studies were identified.The results of Mete-analysis indicated that better efficacy of treatment by acupoint injection combining west medicine or Chinese patent medicine than single west medicine is obviously demonstrated, and the effects,vary in different Chinese medicine.The methodological qualities are considered low in these studies.Conclusions:Based on the aforementioned results, conclusions could be drawn as treatment on AR by acu