个体化医疗的现状与未来生物标志物.pptVIP

个体化医疗的现状与未来四. 生物标志物研究 吕林莉 M.D., Ph.D. 东南大学医学院 Outline 生物标志物的概念 如何评价生物标志物？ 生物标志物的研究方法？ 生物标志物的概念 什么是生物标志物(biomarker)？ “measurable and quantifiable biological parameters” -- a Medical Subject Heading (MeSH) term, 1989 “ A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention.” --Biomarker Definitions Working Group, 2001,NIH Features of a Useful Biomarker High sensitivity and specificity Easy accessible sample Correlation with histological