急性冠脉综合征患者高迁移率族蛋白B1和超敏C反应蛋白的变化及临床意义-@@专业论文.docxVIP

中文摘要急性冠脉综合征患者高迁移率族蛋白 中文摘要 急性冠脉综合征患者高迁移率族蛋白 B1 和超敏 C 反应蛋白的变化及临床意义 急性冠脉综合征患者高迁移率族蛋白 B 急性冠脉综合征患者高迁移率族蛋白 B1 和超敏 C 反应蛋白的变化及临床意义 英文摘要 PAGE PAGE IV III III 关键词：急性冠脉综合征；HMGB1；hs-CRP 作 者：姚云婕 指导教师：陈 弹 The Changes and Clinical Significance of High Mobility Group Box-1 and High Sensitivity C-reactive Protein in patients of acute coronary syndromes Abstract Objectives: explorer the alteration of high mobility group box-1 (HMGB1) and high sensitivity C-reactive protein (hs-CRP) in patients of acute coronary syndromes (ACS), to reveal the relationship between inflammatory factor and ACS. Methods: 57 ACS patients who accepted coronary angiography in our hospital from November 2012 to February 2013 are selected. The patients include 30 acute myocardial infarction (AMI) and 27 unstable angina pectoris (UAP). ACS patients were divided into 33 single-vessel disease, and 24 multi-vessel disease based on the severity of coronary artery Major advense cardiac event (MACE) happened in 9 AMI patients during hospitalization. 26 asymptomatic healthy individuals who underwent annual health check up were chosen as control. Serum HMGB1 were measured by enzyme-linked immunosorbent assay (ELISA). And serum hs-CRP, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were collected. Results: levels of HMGB1 and hs-CRP in ACS patients were all higher than control subjects (P 0.05). There was no significant difference between AMI and UA in levels of HMGB1 (P0.05). Levels of HMGB1 and hs-CRP in ACS patient were positively correlated (γ=0.343, P0.05). Compared with the single-vessel disease, HMGB1 remarkably increased in Multi-vessel disease (P0.05). Levels of HMGB1 and hs-CRP in MACE were higher than non-MACE (P0.05). 英文摘要急性冠脉综合征患者高迁移率族蛋白 英文摘要 急性冠脉综合征患者高迁移率族蛋白 B1 和超敏 C 反应蛋白的变化及临床意义 Conclusions: Serum HMGB1 and hs-CRP levels significantly increase in ACS Patients. Serum HMGB1 and hs-CRP levels were positively correlated