急性白血病患者凝血与纤溶指标的检测及临床意义-内科学(血液病学)专业论文.docxVIP

青海大学医学院 青海大学医学院 2010 级攻读硕士学位研究生毕业论文 - - PAGE 10 - A Clinical Study of Blood Clotting and Fibrinolysis Data in Acute Leukemia Abstract Objective To measure the blood clotting and fibrinolysis in different phrases of patients with acute leukemia，and discuss the diagnosis ,treatment and prognosis． Method The PT、APTT、DD、vWF、AT- III and FIB of 45 patients with acute leukemia and thirty health adults were detected with TSA6000, the results were analyzed in different phrases. The tumor load（leukemia cells）were counted in bone marrow smear in 45 acute leukemia cases． Results Compared with normal control group，plasma levels of vWF were higher before treatment in acute leukemia patients(P 0.01).Compared with normal control group，plasma levels of AT- III was decreased before treatment in acute leukemia patients(P 0.01).The PT and APTT in both group had no difference (P0.05). The DD was increased and FIB decreased in AL group compared with normal control group (P 0.01).Compared with other AL patients, plasma levels of vWF and DD increased and the levels of AT- III and FIB decreased in APL patients before treatment．But the levels in both AML and ALL group had no difference (P0.05).Compared with normal control group， the AT- III and FIB had no difference in Acute Leukemia after complete remission(CR) (P0.05). Compared with normal control group， the vWF and DD had also no difference in Acute Leukemia after complete remission(CR) (P0.05).Compared with AL patients before treatment, the PT、APTT、DD、vWF、AT- III and FIB had also no difference in Acute Leukemia after non- remission(NR) (P0.05)，and compared with normal control group，these were elevated before treatment in acute leukemia patients(P 0.05).There was positive correlation between the total number of tumor load and vWF、DD in Acute Leukemia.And there was negative correlation between tumor load and AT- III、FIB in Acute Leukemia. Conclusion Activation of the injury of vascular endothelium，coagul